Epithelial-Mesenchymal Plasticity Induced by Discontinuous Exposure to TGFβ1 Promotes Tumour Growth

Epithelial-Mesenchymal Plasticity Induced by Discontinuous Exposure to TGFβ1 Promotes Tumour Growth

Transitions between epithelial and mesenchymal cellular states (EMT/MET) contribute to cancer progression. We hypothesize that EMT followed by MET promotes cell population heterogeneity, favouring tumour growth. We developed an EMT model by on and off exposure of epithelial EpH4 cells (E-cells) to T...

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Bibliographic Details
Main Authors: Mafalda Santos, Marta Ferreira, Patrícia Oliveira, Nuno Mendes, Ana André, André F. Vieira, Joana B. Nunes, Joana Carvalho, Sara Rocha, Mafalda Azevedo, Daniel Ferreira, Inês Reis, João Vinagre, Joana Paredes, Alireza Heravi-Moussavi, Jorge Lima, Valdemar Máximo, Angela Burleigh, Calvin Roskelley, Fátima Carneiro, David Huntsman, Carla Oliveira
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biology
Subjects:
MET
cellular heterogeneity
self-Renewal
EMT
tumourigenic potential
Online Access:https://www.mdpi.com/2079-7737/11/7/1046

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