Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes
Background: Asthma has a higher prevalence in athlete populations such as Olympic athletes than in the general population. Correct diagnosis and management of asthma in athletes is important for symptom control and avoidance of doping accusations. However, few reports are available on asthma treatme...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-04-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893014000185 |
| _version_ | 1828731448606064640 |
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| author | Yoshifumi Hoshino Toshiyuki Koya Hiroshi Kagamu Keisuke Tsukioka Mio Toyama Takuro Sakagami Takashi Hasegawa Ichiei Narita Masaaki Arakawa Eiichi Suzuki |
| author_facet | Yoshifumi Hoshino Toshiyuki Koya Hiroshi Kagamu Keisuke Tsukioka Mio Toyama Takuro Sakagami Takashi Hasegawa Ichiei Narita Masaaki Arakawa Eiichi Suzuki |
| author_sort | Yoshifumi Hoshino |
| collection | DOAJ |
| description | Background: Asthma has a higher prevalence in athlete populations such as Olympic athletes than in the general population. Correct diagnosis and management of asthma in athletes is important for symptom control and avoidance of doping accusations. However, few reports are available on asthma treatment in the athlete population in clinical practice. In this study, we focused on the clinical efficacy of inhaled corticosteroid (ICS) for asthma in a Japanese athlete population.
Methods: The study subjects included athletes who visited the Niigata Institute for Health and Sports Medicine, Niigata, Japan for athletic tests and who were diagnosed with asthma on the basis of respiratory symptoms and positive results in a bronchodilator or bronchial provocation test such as exercise, hypertonic saline, or methacholine provocation. The athletes received ICS alone for at least 3 months, and the clinical background, sports type, and treatment efficacy were analyzed.
Results: The study population comprised 80 athletes (59 men and 21 women) with a median age of 16.0 years. Regarding sports type, 28 athletes engaged in winter sports (35%), 22 in endurance sports (27.5%), and 25 in indoor sports (31.3%). Although ICS is the primary treatment in athlete asthma, 16.3% of the athletes showed an unsatisfactory response to treatment according to the Global Evaluation of Treatment Effectiveness (GETE). These subjects were characterized by a decreased response to methacholine and lower values for FEV1/FVC and type 2 helper T cell (Th2)-associated biomarkers relative to responsive athletes. In multivariate analysis, FEV1/FVC and the logarithm to the base 10 of the IgE level were independently associated with the ICS response.
Conclusions: These data suggest that ICS is effective for asthma in most athletes. However, certain asthmatic athletes are less responsive to ICS than expected. The pathogenesis in these subjects may differ from that of conventional asthma characterized by chronic allergic airway inflammation. |
| first_indexed | 2024-04-12T17:46:17Z |
| format | Article |
| id | doaj.art-7303039f465a4b569200b1a00942bc35 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-12T17:46:17Z |
| publishDate | 2015-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-7303039f465a4b569200b1a00942bc352022-12-22T03:22:40ZengElsevierAllergology International1323-89302015-04-0164214514910.1016/j.alit.2014.10.004Effect of inhaled corticosteroids on bronchial asthma in Japanese athletesYoshifumi Hoshino0Toshiyuki Koya1Hiroshi Kagamu2Keisuke Tsukioka3Mio Toyama4Takuro Sakagami5Takashi Hasegawa6Ichiei Narita7Masaaki Arakawa8Eiichi Suzuki9Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Biological Functions and Medical Control, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanDivision of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Biological Functions and Medical Control, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanDivision of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Biological Functions and Medical Control, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanDivision of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Biological Functions and Medical Control, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanDivision of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Biological Functions and Medical Control, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanDivision of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Biological Functions and Medical Control, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanDepartment of General Medicine, Niigata University Medical and Dental Hospital, Niigata, JapanDivision of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Biological Functions and Medical Control, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanNiigata Institute for Health and Sports Medicine, Niigata, JapanDepartment of General Medicine, Niigata University Medical and Dental Hospital, Niigata, JapanBackground: Asthma has a higher prevalence in athlete populations such as Olympic athletes than in the general population. Correct diagnosis and management of asthma in athletes is important for symptom control and avoidance of doping accusations. However, few reports are available on asthma treatment in the athlete population in clinical practice. In this study, we focused on the clinical efficacy of inhaled corticosteroid (ICS) for asthma in a Japanese athlete population. Methods: The study subjects included athletes who visited the Niigata Institute for Health and Sports Medicine, Niigata, Japan for athletic tests and who were diagnosed with asthma on the basis of respiratory symptoms and positive results in a bronchodilator or bronchial provocation test such as exercise, hypertonic saline, or methacholine provocation. The athletes received ICS alone for at least 3 months, and the clinical background, sports type, and treatment efficacy were analyzed. Results: The study population comprised 80 athletes (59 men and 21 women) with a median age of 16.0 years. Regarding sports type, 28 athletes engaged in winter sports (35%), 22 in endurance sports (27.5%), and 25 in indoor sports (31.3%). Although ICS is the primary treatment in athlete asthma, 16.3% of the athletes showed an unsatisfactory response to treatment according to the Global Evaluation of Treatment Effectiveness (GETE). These subjects were characterized by a decreased response to methacholine and lower values for FEV1/FVC and type 2 helper T cell (Th2)-associated biomarkers relative to responsive athletes. In multivariate analysis, FEV1/FVC and the logarithm to the base 10 of the IgE level were independently associated with the ICS response. Conclusions: These data suggest that ICS is effective for asthma in most athletes. However, certain asthmatic athletes are less responsive to ICS than expected. The pathogenesis in these subjects may differ from that of conventional asthma characterized by chronic allergic airway inflammation.http://www.sciencedirect.com/science/article/pii/S1323893014000185Bronchial provocation testFraction of exhaled NOIgEInhaled corticosteroidPulmonary function testing |
| spellingShingle | Yoshifumi Hoshino Toshiyuki Koya Hiroshi Kagamu Keisuke Tsukioka Mio Toyama Takuro Sakagami Takashi Hasegawa Ichiei Narita Masaaki Arakawa Eiichi Suzuki Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes Allergology International Bronchial provocation test Fraction of exhaled NO IgE Inhaled corticosteroid Pulmonary function testing |
| title | Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes |
| title_full | Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes |
| title_fullStr | Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes |
| title_full_unstemmed | Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes |
| title_short | Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes |
| title_sort | effect of inhaled corticosteroids on bronchial asthma in japanese athletes |
| topic | Bronchial provocation test Fraction of exhaled NO IgE Inhaled corticosteroid Pulmonary function testing |
| url | http://www.sciencedirect.com/science/article/pii/S1323893014000185 |
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