Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors

Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors

A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed to evaluate their biological activities. The results were shown that most of the target compounds existed excellent antitumor a...

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Bibliographic Details
Main Authors:	Yaqing Zuo, Rongrong Li, Yan Zhang, Guochen Bao, Yi Le, Longjia Yan
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	EGFR inhibitor pyrimidine antitumor reagent
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2022.2128797

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