Outbreak of Clostridioides difficile infection in Silesian district hospital
INTRODUCTION: In order to evaluate a Clostridioides difficile infection (CDI) outbreak between December 2018 and February 2019 in the internal medicine ward of a district hospital in Silesia, 6 stools from 5 patients were examined. MATERIAL AND METHODS: C. difficile was identified, genes encoding gl...
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| Format: | Article |
| Language: | English |
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Śląski Uniwersytet Medyczny w Katowicach
2023-06-01
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| Series: | Annales Academiae Medicae Silesiensis |
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| Online Access: | https://annales.sum.edu.pl/Outbreak-of-Clostridioides-difficile-infection-in-Silesian-district-hospital,158921,0,2.html |
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| author | Klaudia T. Szarek Monika A. Kabała Krzysztof Sacha Franciszek Drzymała Adam Borek Monika Pomorska-Wesołowska Małgorzata Aptekorz Gayane Martirosian |
| author_facet | Klaudia T. Szarek Monika A. Kabała Krzysztof Sacha Franciszek Drzymała Adam Borek Monika Pomorska-Wesołowska Małgorzata Aptekorz Gayane Martirosian |
| author_sort | Klaudia T. Szarek |
| collection | DOAJ |
| description | INTRODUCTION: In order to evaluate a Clostridioides difficile infection (CDI) outbreak between December 2018 and February 2019 in the internal medicine ward of a district hospital in Silesia, 6 stools from 5 patients were examined. MATERIAL AND METHODS: C. difficile was identified, genes encoding glutamate dehydrogenase (GDH) – gluD, A/B – tcdA/tcdB and binary – cdtA/cdtB toxins, ermB were determined by mPCR and antibiotic resistance by means of E-Tests. RESULTS: Women predominated among the patients (4/5). All the 6 C. difficile isolates belonged to hyperepidemic ribotype 027, were positive for all genes and were resistant to moxifloxacin, erythromycin, clindamycin, rifampicin, imipenem, and chloramphenicol. CONCLUSIONS: The obtained results indicate that the hyperepidemic C. difficile clone is spreading in the ward. |
| first_indexed | 2024-03-13T03:53:53Z |
| format | Article |
| id | doaj.art-73075992b96a46b093849c14f6b048bb |
| institution | Directory Open Access Journal |
| issn | 1734-025X |
| language | English |
| last_indexed | 2024-03-13T03:53:53Z |
| publishDate | 2023-06-01 |
| publisher | Śląski Uniwersytet Medyczny w Katowicach |
| record_format | Article |
| series | Annales Academiae Medicae Silesiensis |
| spelling | doaj.art-73075992b96a46b093849c14f6b048bb2023-06-22T09:09:53ZengŚląski Uniwersytet Medyczny w KatowicachAnnales Academiae Medicae Silesiensis1734-025X2023-06-0177758110.18794/aams/158921Outbreak of Clostridioides difficile infection in Silesian district hospitalKlaudia T. Szarek0Monika A. Kabała1https://orcid.org/0000-0003-4234-586XKrzysztof Sacha2https://orcid.org/0000-0001-7591-1253Franciszek Drzymała3Adam Borek4Monika Pomorska-Wesołowska5https://orcid.org/0000-0002-8954-288XMałgorzata Aptekorz6https://orcid.org/0000-0002-7343-4702Gayane Martirosian7https://orcid.org/0000-0002-0311-0884Department of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland / Katedra i Zakład Mikrobiologii Lekarskiej, Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w KatowicachDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland / Katedra i Zakład Mikrobiologii Lekarskiej, Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w KatowicachDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland / Katedra i Zakład Mikrobiologii Lekarskiej, Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w KatowicachStudent Research Group, Department of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland / Studenckie Koło Naukowe przy Katedrze i Zakładzie Mikrobiologii Lekarskiej, Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w KatowicachStudent Research Group, Department of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland / Studenckie Koło Naukowe przy Katedrze i Zakładzie Mikrobiologii Lekarskiej, Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w KatowicachDepartment of Microbiology, KORLAB Medical Laboratory, Ruda Śląska, Poland / Pracownia Mikrobiologii, KORLAB Laboratoria Medyczne, Ruda ŚląskaDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland / Katedra i Zakład Mikrobiologii Lekarskiej, Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w KatowicachDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland / Katedra i Zakład Mikrobiologii Lekarskiej, Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w KatowicachINTRODUCTION: In order to evaluate a Clostridioides difficile infection (CDI) outbreak between December 2018 and February 2019 in the internal medicine ward of a district hospital in Silesia, 6 stools from 5 patients were examined. MATERIAL AND METHODS: C. difficile was identified, genes encoding glutamate dehydrogenase (GDH) – gluD, A/B – tcdA/tcdB and binary – cdtA/cdtB toxins, ermB were determined by mPCR and antibiotic resistance by means of E-Tests. RESULTS: Women predominated among the patients (4/5). All the 6 C. difficile isolates belonged to hyperepidemic ribotype 027, were positive for all genes and were resistant to moxifloxacin, erythromycin, clindamycin, rifampicin, imipenem, and chloramphenicol. CONCLUSIONS: The obtained results indicate that the hyperepidemic C. difficile clone is spreading in the ward.https://annales.sum.edu.pl/Outbreak-of-Clostridioides-difficile-infection-in-Silesian-district-hospital,158921,0,2.htmlclostridioides difficile infectionoutbreakclostridioides difficile toxins |
| spellingShingle | Klaudia T. Szarek Monika A. Kabała Krzysztof Sacha Franciszek Drzymała Adam Borek Monika Pomorska-Wesołowska Małgorzata Aptekorz Gayane Martirosian Outbreak of Clostridioides difficile infection in Silesian district hospital Annales Academiae Medicae Silesiensis clostridioides difficile infection outbreak clostridioides difficile toxins |
| title | Outbreak of Clostridioides difficile infection in Silesian district hospital |
| title_full | Outbreak of Clostridioides difficile infection in Silesian district hospital |
| title_fullStr | Outbreak of Clostridioides difficile infection in Silesian district hospital |
| title_full_unstemmed | Outbreak of Clostridioides difficile infection in Silesian district hospital |
| title_short | Outbreak of Clostridioides difficile infection in Silesian district hospital |
| title_sort | outbreak of clostridioides difficile infection in silesian district hospital |
| topic | clostridioides difficile infection outbreak clostridioides difficile toxins |
| url | https://annales.sum.edu.pl/Outbreak-of-Clostridioides-difficile-infection-in-Silesian-district-hospital,158921,0,2.html |
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