Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption

Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption

Drug absorption across viable porcine intestines was investigated using an Ussing chamber system. The apparent permeability coefficients, <i>P<sub>app,pig</sub></i>, were compared to the permeability coefficients determined in humans in vivo, <i>P<sub>eff,human<...

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Bibliographic Details
Main Authors: Yvonne E. Arnold, Julien Thorens, Stéphane Bernard, Yogeshvar N. Kalia
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Pharmaceutics
Subjects:
intestinal permeability
regional drug absorption
Ussing chamber
biorelevant media
P-gp
CYP3A4
Online Access:https://www.mdpi.com/1999-4923/11/3/139

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