Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity

Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity

Human kidney epithelial cells are supposed to be directly involved in the pathogenesis of the hemolytic–uremic syndrome (HUS) caused by Shiga toxin (Stx)-producing enterohemorrhagic <i>Escherichia coli</i> (EHEC). The characterization of the major and minor Stx-binding glycosphingolipids...

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Bibliographic Details
Main Authors: Johanna Detzner, Elisabeth Krojnewski, Gottfried Pohlentz, Daniel Steil, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Toxins
Subjects:
pHRCEpiCs
EHEC
kidney cortical epithelial cells
glycolipids
receptor
Shiga toxin
Online Access:https://www.mdpi.com/2072-6651/13/2/139

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