Anti-inflammatory effects of trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (THSG) from Polygonum multiflorum (PM) and hypoglycemic effect of cis-THSG enriched PM extract
Polygonum multiflorum (PM) has been used as a tonic edible plant and is a popular anti-ageing dietary supplement. Trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (trans-THSG) is the major active compound in PM. It was found to have potent anti-inflammatory effects in RAW 264.7 macrophage c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617302013 |
| _version_ | 1818722937404915712 |
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| author | Wenping Tang Shiming Li Yue Liu Mou-Tuan Huang Chi-Tang Ho |
| author_facet | Wenping Tang Shiming Li Yue Liu Mou-Tuan Huang Chi-Tang Ho |
| author_sort | Wenping Tang |
| collection | DOAJ |
| description | Polygonum multiflorum (PM) has been used as a tonic edible plant and is a popular anti-ageing dietary supplement. Trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (trans-THSG) is the major active compound in PM. It was found to have potent anti-inflammatory effects in RAW 264.7 macrophage cells and in TPA-induced mouse ear edema model. Research in the significance and rational of traditional process of post-harvested PM has been neglected. With the aid of modern analytical technology, we studied the major phytochemical transformation of PM solution from trans- to cis-THSG under UV light, reminiscent of traditional process, and further evaluated the hypoglycemic effects of the processed PM extract. In a high fat diet-induced type 2 diabetic mice model, processed PM extract containing cis- and trans-THSG (ratio = 2:3) exhibited significant hypoglycemic capacity, while pure trans-THSG and unprocessed PM extract (cis-/trans-THSG ratio = 1:20) did not, suggesting the importance of anti-diabetic effect of cis-THSG and PM natural process. |
| first_indexed | 2024-12-17T21:02:34Z |
| format | Article |
| id | doaj.art-73087adaa385402dbd8d996ce7c58166 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T21:02:34Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-73087adaa385402dbd8d996ce7c581662022-12-21T21:32:41ZengElsevierJournal of Functional Foods1756-46462017-07-013416Anti-inflammatory effects of trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (THSG) from Polygonum multiflorum (PM) and hypoglycemic effect of cis-THSG enriched PM extractWenping Tang0Shiming Li1Yue Liu2Mou-Tuan Huang3Chi-Tang Ho4Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Hubei Collaborative Innovation Center for Characteristic Resources Exploitation of Dabieshan, Huanggang Normal University, Hubei, China; Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USAHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Hubei Collaborative Innovation Center for Characteristic Resources Exploitation of Dabieshan, Huanggang Normal University, Hubei, China; Corresponding authors.Department of Chemical Biology, Rutgers-The State University of New Jersey, Piscataway, NJ 08854, USADepartment of Chemical Biology, Rutgers-The State University of New Jersey, Piscataway, NJ 08854, USADepartment of Food Science, Rutgers University, New Brunswick, NJ 08901, USA; Corresponding authors.Polygonum multiflorum (PM) has been used as a tonic edible plant and is a popular anti-ageing dietary supplement. Trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (trans-THSG) is the major active compound in PM. It was found to have potent anti-inflammatory effects in RAW 264.7 macrophage cells and in TPA-induced mouse ear edema model. Research in the significance and rational of traditional process of post-harvested PM has been neglected. With the aid of modern analytical technology, we studied the major phytochemical transformation of PM solution from trans- to cis-THSG under UV light, reminiscent of traditional process, and further evaluated the hypoglycemic effects of the processed PM extract. In a high fat diet-induced type 2 diabetic mice model, processed PM extract containing cis- and trans-THSG (ratio = 2:3) exhibited significant hypoglycemic capacity, while pure trans-THSG and unprocessed PM extract (cis-/trans-THSG ratio = 1:20) did not, suggesting the importance of anti-diabetic effect of cis-THSG and PM natural process.http://www.sciencedirect.com/science/article/pii/S1756464617302013DiabetesStilbene glycosidePolygonum multiflorumHypoglycemic activityHOMA |
| spellingShingle | Wenping Tang Shiming Li Yue Liu Mou-Tuan Huang Chi-Tang Ho Anti-inflammatory effects of trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (THSG) from Polygonum multiflorum (PM) and hypoglycemic effect of cis-THSG enriched PM extract Journal of Functional Foods Diabetes Stilbene glycoside Polygonum multiflorum Hypoglycemic activity HOMA |
| title | Anti-inflammatory effects of trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (THSG) from Polygonum multiflorum (PM) and hypoglycemic effect of cis-THSG enriched PM extract |
| title_full | Anti-inflammatory effects of trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (THSG) from Polygonum multiflorum (PM) and hypoglycemic effect of cis-THSG enriched PM extract |
| title_fullStr | Anti-inflammatory effects of trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (THSG) from Polygonum multiflorum (PM) and hypoglycemic effect of cis-THSG enriched PM extract |
| title_full_unstemmed | Anti-inflammatory effects of trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (THSG) from Polygonum multiflorum (PM) and hypoglycemic effect of cis-THSG enriched PM extract |
| title_short | Anti-inflammatory effects of trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (THSG) from Polygonum multiflorum (PM) and hypoglycemic effect of cis-THSG enriched PM extract |
| title_sort | anti inflammatory effects of trans 2 3 5 4 tetrahydroxystilbene 2 o β glucopyranoside thsg from polygonum multiflorum pm and hypoglycemic effect of cis thsg enriched pm extract |
| topic | Diabetes Stilbene glycoside Polygonum multiflorum Hypoglycemic activity HOMA |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617302013 |
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