Longitudinal Assessment of Serum 25-Hydroxyvitamin D Levels during Pregnancy and Postpartum—Are the Current Recommendations for Supplementation Sufficient?
(1) Background: Pregnant women are at risk of vitamin D deficiency. Data on pregnancy outcomes in women with vitamin D deficiency during pregnancy are controversial, and prospective longitudinal data on vitamin D deficiency with consistent definitions in pregnant women are scarce. (2) Methods: The a...
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MDPI AG
2023-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/2/339 |
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| author | Pilar Palmrich Alexandra Thajer Nawa Schirwani Christina Haberl Harald Zeisler Robin Ristl Julia Binder |
| author_facet | Pilar Palmrich Alexandra Thajer Nawa Schirwani Christina Haberl Harald Zeisler Robin Ristl Julia Binder |
| author_sort | Pilar Palmrich |
| collection | DOAJ |
| description | (1) Background: Pregnant women are at risk of vitamin D deficiency. Data on pregnancy outcomes in women with vitamin D deficiency during pregnancy are controversial, and prospective longitudinal data on vitamin D deficiency with consistent definitions in pregnant women are scarce. (2) Methods: The aim of this prospective longitudinal cohort study was to investigate 25-hydroxyvitamin D levels over the course of pregnancy and postpartum in singleton and twin pregnancies with regard to dietary and supplemental vitamin D intake and environmental factors influencing vitamin D levels, evaluated by a standardized food frequency questionnaire. (3) Results: We included 198 healthy singleton and 51 twin pregnancies for analysis. A total of 967 study visits were performed over a 3-year period. Overall, 59.5% of pregnant women were classified as vitamin D deficient in the first trimester, 54.8% in the second trimester, 58.5% in the third trimester, 66.9% at birth, and 60% 12 weeks postpartum, even though 66.4% of the study population reported daily pregnancy vitamin intake containing vitamin D. Dietary vitamin D intake did not affect vitamin D levels significantly. (4) Conclusions: The majority of pregnant women evaluated in this study were vitamin D deficient, despite administration of pregnancy vitamins containing vitamin D. Individualized vitamin D assessment during pregnancy should be considered to ensure adequate supplementation and prevention of hypovitaminosis D. |
| first_indexed | 2024-03-09T11:31:36Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:31:36Z |
| publishDate | 2023-01-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-730aa66e6418442989f17f7e5613ac7b2023-11-30T23:50:16ZengMDPI AGNutrients2072-66432023-01-0115233910.3390/nu15020339Longitudinal Assessment of Serum 25-Hydroxyvitamin D Levels during Pregnancy and Postpartum—Are the Current Recommendations for Supplementation Sufficient?Pilar Palmrich0Alexandra Thajer1Nawa Schirwani2Christina Haberl3Harald Zeisler4Robin Ristl5Julia Binder6Department of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, 1090 Vienna, AustriaDivision of Neonatology, Department of Pediatrics and Adolescent Medicine, Pediatric Intensive Care Medicine and Neuropediatrics, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, 1090 Vienna, AustriaCenter for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, 1090 Vienna, Austria(1) Background: Pregnant women are at risk of vitamin D deficiency. Data on pregnancy outcomes in women with vitamin D deficiency during pregnancy are controversial, and prospective longitudinal data on vitamin D deficiency with consistent definitions in pregnant women are scarce. (2) Methods: The aim of this prospective longitudinal cohort study was to investigate 25-hydroxyvitamin D levels over the course of pregnancy and postpartum in singleton and twin pregnancies with regard to dietary and supplemental vitamin D intake and environmental factors influencing vitamin D levels, evaluated by a standardized food frequency questionnaire. (3) Results: We included 198 healthy singleton and 51 twin pregnancies for analysis. A total of 967 study visits were performed over a 3-year period. Overall, 59.5% of pregnant women were classified as vitamin D deficient in the first trimester, 54.8% in the second trimester, 58.5% in the third trimester, 66.9% at birth, and 60% 12 weeks postpartum, even though 66.4% of the study population reported daily pregnancy vitamin intake containing vitamin D. Dietary vitamin D intake did not affect vitamin D levels significantly. (4) Conclusions: The majority of pregnant women evaluated in this study were vitamin D deficient, despite administration of pregnancy vitamins containing vitamin D. Individualized vitamin D assessment during pregnancy should be considered to ensure adequate supplementation and prevention of hypovitaminosis D.https://www.mdpi.com/2072-6643/15/2/339maternal medicinepregnancyvitamin Dhypovitaminosis |
| spellingShingle | Pilar Palmrich Alexandra Thajer Nawa Schirwani Christina Haberl Harald Zeisler Robin Ristl Julia Binder Longitudinal Assessment of Serum 25-Hydroxyvitamin D Levels during Pregnancy and Postpartum—Are the Current Recommendations for Supplementation Sufficient? Nutrients maternal medicine pregnancy vitamin D hypovitaminosis |
| title | Longitudinal Assessment of Serum 25-Hydroxyvitamin D Levels during Pregnancy and Postpartum—Are the Current Recommendations for Supplementation Sufficient? |
| title_full | Longitudinal Assessment of Serum 25-Hydroxyvitamin D Levels during Pregnancy and Postpartum—Are the Current Recommendations for Supplementation Sufficient? |
| title_fullStr | Longitudinal Assessment of Serum 25-Hydroxyvitamin D Levels during Pregnancy and Postpartum—Are the Current Recommendations for Supplementation Sufficient? |
| title_full_unstemmed | Longitudinal Assessment of Serum 25-Hydroxyvitamin D Levels during Pregnancy and Postpartum—Are the Current Recommendations for Supplementation Sufficient? |
| title_short | Longitudinal Assessment of Serum 25-Hydroxyvitamin D Levels during Pregnancy and Postpartum—Are the Current Recommendations for Supplementation Sufficient? |
| title_sort | longitudinal assessment of serum 25 hydroxyvitamin d levels during pregnancy and postpartum are the current recommendations for supplementation sufficient |
| topic | maternal medicine pregnancy vitamin D hypovitaminosis |
| url | https://www.mdpi.com/2072-6643/15/2/339 |
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