Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study
Obesity and metabolic syndrome are strong risk factors for incident chronic kidney disease (CKD). However, the predictive accuracy of metabolic body composition status (MBCS), which combines the status of obesity and metabolic syndrome, for rapid kidney function decline (RKFD) is unclear. The aim of...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.895787/full |
| _version_ | 1811255914647257088 |
|---|---|
| author | Shao-Chi Chu Po-Hsi Wang Kuan-Ying Lu Chia-Chun Ko Yun-Hsuan She Chin-Chan Lee Chin-Chan Lee Chin-Chan Lee I-Wen Wu I-Wen Wu I-Wen Wu Chiao-Yin Sun Chiao-Yin Sun Heng-Jung Hsu Heng-Jung Hsu Heng-Jung Hsu Heng-Chih Pan Heng-Chih Pan Heng-Chih Pan Heng-Chih Pan |
| author_facet | Shao-Chi Chu Po-Hsi Wang Kuan-Ying Lu Chia-Chun Ko Yun-Hsuan She Chin-Chan Lee Chin-Chan Lee Chin-Chan Lee I-Wen Wu I-Wen Wu I-Wen Wu Chiao-Yin Sun Chiao-Yin Sun Heng-Jung Hsu Heng-Jung Hsu Heng-Jung Hsu Heng-Chih Pan Heng-Chih Pan Heng-Chih Pan Heng-Chih Pan |
| author_sort | Shao-Chi Chu |
| collection | DOAJ |
| description | Obesity and metabolic syndrome are strong risk factors for incident chronic kidney disease (CKD). However, the predictive accuracy of metabolic body composition status (MBCS), which combines the status of obesity and metabolic syndrome, for rapid kidney function decline (RKFD) is unclear. The aim of this study was to investigate the relationship between MBCS and RKFD in a healthy population in a prospective community-based cohort study. In the current study, we followed changes in renal function in 731 people residing in northern Taiwan for 5 years. The participants were divided into four groups according to their MBCS, including metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight (MUOW). We evaluated traditional risk factors for CKD and metabolic profiles. The primary outcome was RKFD, which was defined as a 15% decline in estimated glomerular filtration rate (eGFR) within the first 4 years, and a reduction in eGFR which did not improve in the 5th year. During the study period, a total of 731 participants were enrolled. The incidence of RKFD was 17.1% (125/731). Multiple Cox logistic regression hazard analysis revealed that age, cerebrovascular accident, eGFR, urine albumin-to-creatinine ratio, use of painkillers, depressive mood, MUNW and MUOW were independent predictors of RKFD. After adjusting for age, sex, eGFR and total cholesterol, the participants with MUNW and MUOW had higher hazard ratios (HRs) for RKFD [HR: 2.19, 95% confidence interval (CI): 1.22–3.95 for MUNW; HR: 1.86, 95% CI: 1.21–2.87 for MUOW] than those with MHNW. Similar results were also observed in subgroup analysis of those aged above 65 years. On the basis of the results of this study, we conclude that MBCS was independently associated with RKFD, especially in the older adults. On the basis of our results, we suggest that MUNW and MUOW should be considered as risk factors for RKFD. |
| first_indexed | 2024-04-12T17:31:04Z |
| format | Article |
| id | doaj.art-730b53bfb34044658ab553da2f41fb33 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-12T17:31:04Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-730b53bfb34044658ab553da2f41fb332022-12-22T03:23:07ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-06-011010.3389/fpubh.2022.895787895787Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational StudyShao-Chi Chu0Po-Hsi Wang1Kuan-Ying Lu2Chia-Chun Ko3Yun-Hsuan She4Chin-Chan Lee5Chin-Chan Lee6Chin-Chan Lee7I-Wen Wu8I-Wen Wu9I-Wen Wu10Chiao-Yin Sun11Chiao-Yin Sun12Heng-Jung Hsu13Heng-Jung Hsu14Heng-Jung Hsu15Heng-Chih Pan16Heng-Chih Pan17Heng-Chih Pan18Heng-Chih Pan19Division of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanDivision of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanDivision of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanDivision of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanDivision of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanDivision of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanCommunity Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanDivision of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanCommunity Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanDivision of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanCommunity Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanDivision of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanCommunity Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, TaiwanObesity and metabolic syndrome are strong risk factors for incident chronic kidney disease (CKD). However, the predictive accuracy of metabolic body composition status (MBCS), which combines the status of obesity and metabolic syndrome, for rapid kidney function decline (RKFD) is unclear. The aim of this study was to investigate the relationship between MBCS and RKFD in a healthy population in a prospective community-based cohort study. In the current study, we followed changes in renal function in 731 people residing in northern Taiwan for 5 years. The participants were divided into four groups according to their MBCS, including metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight (MUOW). We evaluated traditional risk factors for CKD and metabolic profiles. The primary outcome was RKFD, which was defined as a 15% decline in estimated glomerular filtration rate (eGFR) within the first 4 years, and a reduction in eGFR which did not improve in the 5th year. During the study period, a total of 731 participants were enrolled. The incidence of RKFD was 17.1% (125/731). Multiple Cox logistic regression hazard analysis revealed that age, cerebrovascular accident, eGFR, urine albumin-to-creatinine ratio, use of painkillers, depressive mood, MUNW and MUOW were independent predictors of RKFD. After adjusting for age, sex, eGFR and total cholesterol, the participants with MUNW and MUOW had higher hazard ratios (HRs) for RKFD [HR: 2.19, 95% confidence interval (CI): 1.22–3.95 for MUNW; HR: 1.86, 95% CI: 1.21–2.87 for MUOW] than those with MHNW. Similar results were also observed in subgroup analysis of those aged above 65 years. On the basis of the results of this study, we conclude that MBCS was independently associated with RKFD, especially in the older adults. On the basis of our results, we suggest that MUNW and MUOW should be considered as risk factors for RKFD.https://www.frontiersin.org/articles/10.3389/fpubh.2022.895787/fullmetabolic body composition statusmetabolic syndromeobesityrapid kidney function declinechronic kidney disease |
| spellingShingle | Shao-Chi Chu Po-Hsi Wang Kuan-Ying Lu Chia-Chun Ko Yun-Hsuan She Chin-Chan Lee Chin-Chan Lee Chin-Chan Lee I-Wen Wu I-Wen Wu I-Wen Wu Chiao-Yin Sun Chiao-Yin Sun Heng-Jung Hsu Heng-Jung Hsu Heng-Jung Hsu Heng-Chih Pan Heng-Chih Pan Heng-Chih Pan Heng-Chih Pan Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study Frontiers in Public Health metabolic body composition status metabolic syndrome obesity rapid kidney function decline chronic kidney disease |
| title | Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study |
| title_full | Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study |
| title_fullStr | Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study |
| title_full_unstemmed | Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study |
| title_short | Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study |
| title_sort | relationships between metabolic body composition status and rapid kidney function decline in a community based population a prospective observational study |
| topic | metabolic body composition status metabolic syndrome obesity rapid kidney function decline chronic kidney disease |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.895787/full |
| work_keys_str_mv | AT shaochichu relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT pohsiwang relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT kuanyinglu relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT chiachunko relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT yunhsuanshe relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT chinchanlee relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT chinchanlee relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT chinchanlee relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT iwenwu relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT iwenwu relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT iwenwu relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT chiaoyinsun relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT chiaoyinsun relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT hengjunghsu relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT hengjunghsu relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT hengjunghsu relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT hengchihpan relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT hengchihpan relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT hengchihpan relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy AT hengchihpan relationshipsbetweenmetabolicbodycompositionstatusandrapidkidneyfunctiondeclineinacommunitybasedpopulationaprospectiveobservationalstudy |