The study of bone mineral density measured by quantitative computed tomography in middle-aged and elderly men with abnormal glucose metabolism
Abstract Background To investigate the value of quantitative computed tomography (QCT) measurement of bone mineral density (BMD) in middle-aged and elderly men with abnormal blood glucose. Methods Total 138 men aged above 50 years old with routine physical examination were involved in the study. All...
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| Format: | Article |
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BMC
2022-07-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-022-01076-6 |
| _version_ | 1811323578217398272 |
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| author | Pei Zhang Xiaofeng Huang Yanping Gong Yanhui Lu Minyan Liu Xiaoling Cheng Nan Li Chunlin Li |
| author_facet | Pei Zhang Xiaofeng Huang Yanping Gong Yanhui Lu Minyan Liu Xiaoling Cheng Nan Li Chunlin Li |
| author_sort | Pei Zhang |
| collection | DOAJ |
| description | Abstract Background To investigate the value of quantitative computed tomography (QCT) measurement of bone mineral density (BMD) in middle-aged and elderly men with abnormal blood glucose. Methods Total 138 men aged above 50 years old with routine physical examination were involved in the study. All participants were evaluated with serological index, BMD by QCT and dual energy X-ray absorptiometry (DXA). Statistical analysis was conducted by χ2 test and regression model. Results All individuals were divided into normal blood glucose (NBG) group and abnormal blood glucose (ABG) group. Compared with NBG group, BMD detected by QCT was obviously lower in ABG group (P < 0.05). More cases with low bone mass or osteoporosis were detected by QCT measurement than DXA (χ2 = 56.618, P = 0.000), which were consistent in both NBG and ABG groups (χ2 was 33.564 and 23.250, P = 0.000). No significant difference of detection rates was found in both subgroups neither by QCT nor DXA measurement (χ2 = 4.204, P = 0.122). Regression analysis revealed that ABG was negatively associated with BMD assessed by QCT (β = -0.217, P < 0.05), which did not show statistical difference after adjusting for age. Conclusion In middle-aged and elderly male patients with NBG or ABG, QCT manifests higher detection rates of low bone mass and osteoporosis than DXA. ABG is negatively correlated with BMD measured by QCT, which is affected by age. |
| first_indexed | 2024-04-13T13:58:45Z |
| format | Article |
| id | doaj.art-730d2b24d44b49eaa00734a441b747d2 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-13T13:58:45Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-730d2b24d44b49eaa00734a441b747d22022-12-22T02:44:07ZengBMCBMC Endocrine Disorders1472-68232022-07-012211610.1186/s12902-022-01076-6The study of bone mineral density measured by quantitative computed tomography in middle-aged and elderly men with abnormal glucose metabolismPei Zhang0Xiaofeng Huang1Yanping Gong2Yanhui Lu3Minyan Liu4Xiaoling Cheng5Nan Li6Chunlin Li7School of Medicine, Nankai UniversityDepartment of Endocrinology, the Second Medical Center, the People’s Liberation Army General Hospital, National Clinical Research Center for Geriatric DiseaseDepartment of Endocrinology, the Second Medical Center, the People’s Liberation Army General Hospital, National Clinical Research Center for Geriatric DiseaseDepartment of Endocrinology, the Second Medical Center, the People’s Liberation Army General Hospital, National Clinical Research Center for Geriatric DiseaseDepartment of Endocrinology, the Second Medical Center, the People’s Liberation Army General Hospital, National Clinical Research Center for Geriatric DiseaseDepartment of Endocrinology, the Second Medical Center, the People’s Liberation Army General Hospital, National Clinical Research Center for Geriatric DiseaseDepartment of Endocrinology, the Second Medical Center, the People’s Liberation Army General Hospital, National Clinical Research Center for Geriatric DiseaseSchool of Medicine, Nankai UniversityAbstract Background To investigate the value of quantitative computed tomography (QCT) measurement of bone mineral density (BMD) in middle-aged and elderly men with abnormal blood glucose. Methods Total 138 men aged above 50 years old with routine physical examination were involved in the study. All participants were evaluated with serological index, BMD by QCT and dual energy X-ray absorptiometry (DXA). Statistical analysis was conducted by χ2 test and regression model. Results All individuals were divided into normal blood glucose (NBG) group and abnormal blood glucose (ABG) group. Compared with NBG group, BMD detected by QCT was obviously lower in ABG group (P < 0.05). More cases with low bone mass or osteoporosis were detected by QCT measurement than DXA (χ2 = 56.618, P = 0.000), which were consistent in both NBG and ABG groups (χ2 was 33.564 and 23.250, P = 0.000). No significant difference of detection rates was found in both subgroups neither by QCT nor DXA measurement (χ2 = 4.204, P = 0.122). Regression analysis revealed that ABG was negatively associated with BMD assessed by QCT (β = -0.217, P < 0.05), which did not show statistical difference after adjusting for age. Conclusion In middle-aged and elderly male patients with NBG or ABG, QCT manifests higher detection rates of low bone mass and osteoporosis than DXA. ABG is negatively correlated with BMD measured by QCT, which is affected by age.https://doi.org/10.1186/s12902-022-01076-6QCTBone mineral densityAging menGlucose metabolism |
| spellingShingle | Pei Zhang Xiaofeng Huang Yanping Gong Yanhui Lu Minyan Liu Xiaoling Cheng Nan Li Chunlin Li The study of bone mineral density measured by quantitative computed tomography in middle-aged and elderly men with abnormal glucose metabolism BMC Endocrine Disorders QCT Bone mineral density Aging men Glucose metabolism |
| title | The study of bone mineral density measured by quantitative computed tomography in middle-aged and elderly men with abnormal glucose metabolism |
| title_full | The study of bone mineral density measured by quantitative computed tomography in middle-aged and elderly men with abnormal glucose metabolism |
| title_fullStr | The study of bone mineral density measured by quantitative computed tomography in middle-aged and elderly men with abnormal glucose metabolism |
| title_full_unstemmed | The study of bone mineral density measured by quantitative computed tomography in middle-aged and elderly men with abnormal glucose metabolism |
| title_short | The study of bone mineral density measured by quantitative computed tomography in middle-aged and elderly men with abnormal glucose metabolism |
| title_sort | study of bone mineral density measured by quantitative computed tomography in middle aged and elderly men with abnormal glucose metabolism |
| topic | QCT Bone mineral density Aging men Glucose metabolism |
| url | https://doi.org/10.1186/s12902-022-01076-6 |
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