Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids
Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. Modulation of the gut microbiota was proposed as underlying factor as well as a novel measure to prevent and treat hyperlipidemia. The effects of GP on high-fat diet (HFD)-induced hyperlipidemia and g...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Food Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927122002532 |
| _version_ | 1827919380166475776 |
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| author | Aijun Tong Weihao Wu Zhengxin Chen Jiahui Wen Ruibo Jia Bin Liu Hui Cao Chao Zhao |
| author_facet | Aijun Tong Weihao Wu Zhengxin Chen Jiahui Wen Ruibo Jia Bin Liu Hui Cao Chao Zhao |
| author_sort | Aijun Tong |
| collection | DOAJ |
| description | Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. Modulation of the gut microbiota was proposed as underlying factor as well as a novel measure to prevent and treat hyperlipidemia. The effects of GP on high-fat diet (HFD)-induced hyperlipidemia and gut microbiota modulation were determined in rats. Ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS-MS) indicated that GP were enriched with ganoderic acids G, B, H, A, and F. After feeding with GP supplementation, serum lipid levels including total triglyceride, total cholesterol, and low-density-lipoprotein cholesterol were significantly decreased in hyperlipidemic rats. Furthermore, administration of GP also has reversed the HFD-induced gut microbiota dysbiosis, including a significant increase in Alloprevotella and reduced proportion of Blautia. The result above suggests that GP would be developed as a functional food to ameliorate lipid metabolic disorders and hyperlipidemia. |
| first_indexed | 2024-03-13T03:56:59Z |
| format | Article |
| id | doaj.art-730e9002c5744759a2c6c9b5bd789726 |
| institution | Directory Open Access Journal |
| issn | 2665-9271 |
| language | English |
| last_indexed | 2024-03-13T03:56:59Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj.art-730e9002c5744759a2c6c9b5bd7897262023-06-22T05:04:50ZengElsevierCurrent Research in Food Science2665-92712023-01-016100427Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoidsAijun Tong0Weihao Wu1Zhengxin Chen2Jiahui Wen3Ruibo Jia4Bin Liu5Hui Cao6Chao Zhao7College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; National Engineering Research Center of Juncao, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Zhanjiang, 524088, China; Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Sciences, 32004, Ourense, Spain; Corresponding author. College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Zhanjiang, 524088, China.College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Corresponding author. College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. Modulation of the gut microbiota was proposed as underlying factor as well as a novel measure to prevent and treat hyperlipidemia. The effects of GP on high-fat diet (HFD)-induced hyperlipidemia and gut microbiota modulation were determined in rats. Ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS-MS) indicated that GP were enriched with ganoderic acids G, B, H, A, and F. After feeding with GP supplementation, serum lipid levels including total triglyceride, total cholesterol, and low-density-lipoprotein cholesterol were significantly decreased in hyperlipidemic rats. Furthermore, administration of GP also has reversed the HFD-induced gut microbiota dysbiosis, including a significant increase in Alloprevotella and reduced proportion of Blautia. The result above suggests that GP would be developed as a functional food to ameliorate lipid metabolic disorders and hyperlipidemia.http://www.sciencedirect.com/science/article/pii/S2665927122002532Ganoderma lucidumTriterpenoidsHyperlipidemiaFecalIntestinal contents |
| spellingShingle | Aijun Tong Weihao Wu Zhengxin Chen Jiahui Wen Ruibo Jia Bin Liu Hui Cao Chao Zhao Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids Current Research in Food Science Ganoderma lucidum Triterpenoids Hyperlipidemia Fecal Intestinal contents |
| title | Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids |
| title_full | Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids |
| title_fullStr | Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids |
| title_full_unstemmed | Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids |
| title_short | Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids |
| title_sort | modulation of gut microbiota and lipid metabolism in rats fed high fat diets by ganoderma lucidum triterpenoids |
| topic | Ganoderma lucidum Triterpenoids Hyperlipidemia Fecal Intestinal contents |
| url | http://www.sciencedirect.com/science/article/pii/S2665927122002532 |
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