Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Abstract Background CD8+ T cells play a critical role in the innate antitumour immune response. Recently, CD8+ T cell dysfunction has been verified in various malignant cancers, including non-small cell lung cancer (NSCLC). However, the molecular biological mechanisms of CD8+ T cell dysfunction in h...

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Bibliographic Details
Main Authors: Shi-Wei Chen, Shu-Qiang Zhu, Xu Pei, Bai-Quan Qiu, Dian Xiong, Xiang Long, Kun Lin, Feng Lu, Jian-Jun Xu, Yong-Bing Wu
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Molecular Cancer
Subjects:
circUSP7
NSCLC
Exosome
Anti-PD1
miR-934
SHP2
Online Access:https://doi.org/10.1186/s12943-021-01448-x

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