TRPV1 Blocker HCRG21 Suppresses TNF-α Production and Prevents the Development of Edema and Hypersensitivity in Carrageenan-Induced Acute Local Inflammation

TRPV1 Blocker HCRG21 Suppresses TNF-α Production and Prevents the Development of Edema and Hypersensitivity in Carrageenan-Induced Acute Local Inflammation

Currently the TRPV1 (transient receptor potential vanilloid type 1) channel is considered to be one of the main targets for pro-inflammatory mediators including TNF-α. Similarly, the inhibition of TRPV1 activity in the peripheral nervous system affects pro-inflammatory mediator production and enhanc...

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Bibliographic Details
Main Authors: Oksana Sintsova, Irina Gladkikh, Anna Klimovich, Yulia Palikova, Viktor Palikov, Olga Styshova, Margarita Monastyrnaya, Igor Dyachenko, Sergey Kozlov, Elena Leychenko
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
TRPV1 inhibition
TNF-α
Kunitz
carrageenan
edema
hypersensitivity
Online Access:https://www.mdpi.com/2227-9059/9/7/716

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