Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions
How testis resident macrophages develop and influence tissue function is not fully understood. Here the authors use mouse lineage tracing methods to document the haematopoietic source, development and recruitment of early testicular macrophages, support of foetal testis differentiation, and interact...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37199-0 |
| _version_ | 1797864219626962944 |
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| author | Xiaowei Gu Anna Heinrich Shu-Yun Li Tony DeFalco |
| author_facet | Xiaowei Gu Anna Heinrich Shu-Yun Li Tony DeFalco |
| author_sort | Xiaowei Gu |
| collection | DOAJ |
| description | How testis resident macrophages develop and influence tissue function is not fully understood. Here the authors use mouse lineage tracing methods to document the haematopoietic source, development and recruitment of early testicular macrophages, support of foetal testis differentiation, and interaction with, and promotion of steroidogenesis in, Leydig cells. |
| first_indexed | 2024-04-09T22:48:13Z |
| format | Article |
| id | doaj.art-730fd7a4027c4576908884a85788b2c3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:48:13Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-730fd7a4027c4576908884a85788b2c32023-03-22T11:43:21ZengNature PortfolioNature Communications2041-17232023-03-0114111710.1038/s41467-023-37199-0Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functionsXiaowei Gu0Anna Heinrich1Shu-Yun Li2Tony DeFalco3Reproductive Sciences Center, Division of Developmental Biology, Cincinnati Children’s Hospital Medical CenterReproductive Sciences Center, Division of Developmental Biology, Cincinnati Children’s Hospital Medical CenterReproductive Sciences Center, Division of Developmental Biology, Cincinnati Children’s Hospital Medical CenterReproductive Sciences Center, Division of Developmental Biology, Cincinnati Children’s Hospital Medical CenterHow testis resident macrophages develop and influence tissue function is not fully understood. Here the authors use mouse lineage tracing methods to document the haematopoietic source, development and recruitment of early testicular macrophages, support of foetal testis differentiation, and interaction with, and promotion of steroidogenesis in, Leydig cells.https://doi.org/10.1038/s41467-023-37199-0 |
| spellingShingle | Xiaowei Gu Anna Heinrich Shu-Yun Li Tony DeFalco Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions Nature Communications |
| title | Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions |
| title_full | Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions |
| title_fullStr | Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions |
| title_full_unstemmed | Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions |
| title_short | Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions |
| title_sort | testicular macrophages are recruited during a narrow fetal time window and promote organ specific developmental functions |
| url | https://doi.org/10.1038/s41467-023-37199-0 |
| work_keys_str_mv | AT xiaoweigu testicularmacrophagesarerecruitedduringanarrowfetaltimewindowandpromoteorganspecificdevelopmentalfunctions AT annaheinrich testicularmacrophagesarerecruitedduringanarrowfetaltimewindowandpromoteorganspecificdevelopmentalfunctions AT shuyunli testicularmacrophagesarerecruitedduringanarrowfetaltimewindowandpromoteorganspecificdevelopmentalfunctions AT tonydefalco testicularmacrophagesarerecruitedduringanarrowfetaltimewindowandpromoteorganspecificdevelopmentalfunctions |