Zieve’s syndrome presenting with coagulopathy, skin and subcutaneous haemorrhage
Zieve syndrome is characterized by hepatic dysfunction, jaundice, hyperlipidaemia, and reversible hemolytic anaemia after alcohol abuse. We report a rare case of this syndrome presenting with coagulopathy and subcutaneous haemorrhage. Laboratory tests showed macrocytic anaemia, hyperbilirubinemia, i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Vilnius University Press
2013-01-01
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| Series: | Acta Medica Lituanica |
| Subjects: | |
| Online Access: | https://www.journals.vu.lt/AML/article/view/21521 |
| _version_ | 1818339100568059904 |
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| author | Jūratė Kondrackienė Inga Beinaravičienė Sigita Gelman Limas Kupčinskas |
| author_facet | Jūratė Kondrackienė Inga Beinaravičienė Sigita Gelman Limas Kupčinskas |
| author_sort | Jūratė Kondrackienė |
| collection | DOAJ |
| description | Zieve syndrome is characterized by hepatic dysfunction, jaundice, hyperlipidaemia, and reversible hemolytic anaemia after alcohol abuse. We report a rare case of this syndrome presenting with coagulopathy and subcutaneous haemorrhage. Laboratory tests showed macrocytic anaemia, hyperbilirubinemia, increased activity of aminotransferases, hyperlipidemia, coagulopathy, signs of haemolysis: reduced concentration of haptoglobin, free hemoglobin. These abnormalities improved during 20 days. Ultrasonography revealed subcutaneous haemorrhagias, liver biopsy was consistent with steatohepatitis. There are a small number of reported cases of Zieve syndrome, and the reason could be the lack of pathognomonic symptoms, rapid decrease of hyperlipidaemic serum levels after alcohol withdrawal, patients denial of drinking. There is no specific treatment, therapy is similar to that for acute alcoholic hepatitis. The Zieve syndrome must be allways considered in the differential diagnosis of uncertain origin liver injury, hemolysis or coagulopathy. |
| first_indexed | 2024-12-13T15:21:38Z |
| format | Article |
| id | doaj.art-7310ce968b2e4219bb9fad0b659a2dac |
| institution | Directory Open Access Journal |
| issn | 1392-0138 2029-4174 |
| language | English |
| last_indexed | 2024-12-13T15:21:38Z |
| publishDate | 2013-01-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Acta Medica Lituanica |
| spelling | doaj.art-7310ce968b2e4219bb9fad0b659a2dac2022-12-21T23:40:34ZengVilnius University PressActa Medica Lituanica1392-01382029-41742013-01-0119410.6001/actamedica.v19i4.2549Zieve’s syndrome presenting with coagulopathy, skin and subcutaneous haemorrhageJūratė KondrackienėInga BeinaravičienėSigita GelmanLimas KupčinskasZieve syndrome is characterized by hepatic dysfunction, jaundice, hyperlipidaemia, and reversible hemolytic anaemia after alcohol abuse. We report a rare case of this syndrome presenting with coagulopathy and subcutaneous haemorrhage. Laboratory tests showed macrocytic anaemia, hyperbilirubinemia, increased activity of aminotransferases, hyperlipidemia, coagulopathy, signs of haemolysis: reduced concentration of haptoglobin, free hemoglobin. These abnormalities improved during 20 days. Ultrasonography revealed subcutaneous haemorrhagias, liver biopsy was consistent with steatohepatitis. There are a small number of reported cases of Zieve syndrome, and the reason could be the lack of pathognomonic symptoms, rapid decrease of hyperlipidaemic serum levels after alcohol withdrawal, patients denial of drinking. There is no specific treatment, therapy is similar to that for acute alcoholic hepatitis. The Zieve syndrome must be allways considered in the differential diagnosis of uncertain origin liver injury, hemolysis or coagulopathy.https://www.journals.vu.lt/AML/article/view/21521Zieve syndromesubcutaneous haemorrhagehyperlipidaemiahemolytic anaemia |
| spellingShingle | Jūratė Kondrackienė Inga Beinaravičienė Sigita Gelman Limas Kupčinskas Zieve’s syndrome presenting with coagulopathy, skin and subcutaneous haemorrhage Acta Medica Lituanica Zieve syndrome subcutaneous haemorrhage hyperlipidaemia hemolytic anaemia |
| title | Zieve’s syndrome presenting with coagulopathy, skin and subcutaneous haemorrhage |
| title_full | Zieve’s syndrome presenting with coagulopathy, skin and subcutaneous haemorrhage |
| title_fullStr | Zieve’s syndrome presenting with coagulopathy, skin and subcutaneous haemorrhage |
| title_full_unstemmed | Zieve’s syndrome presenting with coagulopathy, skin and subcutaneous haemorrhage |
| title_short | Zieve’s syndrome presenting with coagulopathy, skin and subcutaneous haemorrhage |
| title_sort | zieve s syndrome presenting with coagulopathy skin and subcutaneous haemorrhage |
| topic | Zieve syndrome subcutaneous haemorrhage hyperlipidaemia hemolytic anaemia |
| url | https://www.journals.vu.lt/AML/article/view/21521 |
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