Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study
OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2019-03-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100205&lng=en&tlng=en |
| _version_ | 1818470700678119424 |
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| author | Merih Ozgen Didem Turgut Cosan Fulya Doganer Ahu Soyocak Onur Armagan Selen Kuzgun Ayse Merve Aydogan Hasan Veysi Gunes Irfan Degirmenci Fezan Mutlu |
| author_facet | Merih Ozgen Didem Turgut Cosan Fulya Doganer Ahu Soyocak Onur Armagan Selen Kuzgun Ayse Merve Aydogan Hasan Veysi Gunes Irfan Degirmenci Fezan Mutlu |
| author_sort | Merih Ozgen |
| collection | DOAJ |
| description | OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction–restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population. |
| first_indexed | 2024-04-13T21:40:45Z |
| format | Article |
| id | doaj.art-73115fbcf9f346bf9e0c279825070850 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T21:40:45Z |
| publishDate | 2019-03-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-73115fbcf9f346bf9e0c2798250708502022-12-22T02:28:46ZengElsevier EspañaClinics1980-53222019-03-0174010.6061/clinics/2019/e739S1807-59322019000100205Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot studyMerih OzgenDidem Turgut CosanFulya DoganerAhu SoyocakOnur ArmaganSelen KuzgunAyse Merve AydoganHasan Veysi GunesIrfan DegirmenciFezan MutluOBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction–restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100205&lng=en&tlng=enOsteoporosisPolymorphismVitamin K Epoxide Reductase Complex Subunit-1 GeneVertebral Fracture |
| spellingShingle | Merih Ozgen Didem Turgut Cosan Fulya Doganer Ahu Soyocak Onur Armagan Selen Kuzgun Ayse Merve Aydogan Hasan Veysi Gunes Irfan Degirmenci Fezan Mutlu Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study Clinics Osteoporosis Polymorphism Vitamin K Epoxide Reductase Complex Subunit-1 Gene Vertebral Fracture |
| title | Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
| title_full | Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
| title_fullStr | Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
| title_full_unstemmed | Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
| title_short | Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
| title_sort | is there any association between osteoporotic vertebral fracture and vitamin k epoxide reductase complex subunit 1 polymorphism in turkish society a pilot study |
| topic | Osteoporosis Polymorphism Vitamin K Epoxide Reductase Complex Subunit-1 Gene Vertebral Fracture |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100205&lng=en&tlng=en |
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