Prevalence of Non-autoimmune Hypothyroidism in Steroid Resistant Nephrotic Syndrome in Paediatric Age Group
Introduction: It was observed that approximately 10% of children with Nephrotic Syndrome (NS) are found as Steroid Resistant NS (SRNS). The data on the prevalence of non-autoimmune hypothyroidism among the SRNS in India is limited. Aim: To assess the prevalence of non-autoimmune hypothyroidism...
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JCDR Research and Publications Private Limited
2020-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/14077/45530_CE[Ra1]_F(KM)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_GC(RV_SL)_PN(SL).pdf |
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| author | Seema Rani Sinha Rekha Kumari Rakesh Kumar Ravi Shekhar Pritam Prakash Prem Prakash |
| author_facet | Seema Rani Sinha Rekha Kumari Rakesh Kumar Ravi Shekhar Pritam Prakash Prem Prakash |
| author_sort | Seema Rani Sinha |
| collection | DOAJ |
| description | Introduction: It was observed that approximately 10% of children
with Nephrotic Syndrome (NS) are found as Steroid Resistant
NS (SRNS). The data on the prevalence of non-autoimmune
hypothyroidism among the SRNS in India is limited.
Aim: To assess the prevalence of non-autoimmune
hypothyroidism in the case of SRNS.
Materials and Methods: A case control cross-sectional study
was conducted in which 52 cases of SRNS and 52 healthy controls
were enrolled. Thyroid profile like serum Thyroid Stimulating
Hormone (TSH), Free Triiodothyronine (T3), Free Thyroxine (T4)
done in the all cases and controls but anti-Thyroid Peroxidase
(TPO), and anti-thyroglobulin antibody test was done in the case
and control group with deranged thyroid function test. Low Free
T4 (normal: 0.7-2 ng/mL) and elevated serum TSH above the
upper limit of the reference range (>4.5 mIU/L) was defined as
overt hypothyroidism, whereas elevation in serum TSH with a
normal serum FT4 concentration was defined as sub clinical
hypothyroidism. MedCalc statistical software Version 19.2.6
was used to do statistical analysis.
Results: Prevalence of Non-autoimmune hypothyroidism was
38.46% (20 out of 52), 16 (30.76%) had subclinical and 4 (7.69%)
had overt hypothyroidism in case of SRNS in comparison to
1.96% (1 out of 52) in control group. Out of 16 subclinical
hypothyroid patients, two cases with grade 1, 12 cases with
grade 2, and two cases with grade 3 found. Patients with
SRNS had a mean (SD) TSH value of 4.5±4.7 mlU/L which was
significantly higher than control (1.8±1.1 mlU/L). Serum levels of
FT4 were within normal range. Anti-TPO and anti-thyroglobulin
titre were in normal range in children with hypothyroidism.
Conclusion: The prevalence of non-autoimmune hypothyroidism
was high in cases of idiopathic SRNS. So, on the basis of this
study estimation of thyroid profile in children with SRNS seems
to be the rational approach which will lead to early diagnosis
and timely management of hypothyroidism in SRNS. |
| first_indexed | 2024-12-16T14:10:48Z |
| format | Article |
| id | doaj.art-7313b8ead3974df1bd0368fde62d2de5 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-16T14:10:48Z |
| publishDate | 2020-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-7313b8ead3974df1bd0368fde62d2de52022-12-21T22:28:47ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-10-011410BC01BC0410.7860/JCDR/2020/45530.14077Prevalence of Non-autoimmune Hypothyroidism in Steroid Resistant Nephrotic Syndrome in Paediatric Age GroupSeema Rani Sinha0Rekha Kumari1Rakesh Kumar2Ravi Shekhar3Pritam Prakash4Prem Prakash5Tutor, Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Additional Professor, Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Additional Professor, Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Associate Professor, Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Assistant Professor, Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Associate Professor, Department of Surgery, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Introduction: It was observed that approximately 10% of children with Nephrotic Syndrome (NS) are found as Steroid Resistant NS (SRNS). The data on the prevalence of non-autoimmune hypothyroidism among the SRNS in India is limited. Aim: To assess the prevalence of non-autoimmune hypothyroidism in the case of SRNS. Materials and Methods: A case control cross-sectional study was conducted in which 52 cases of SRNS and 52 healthy controls were enrolled. Thyroid profile like serum Thyroid Stimulating Hormone (TSH), Free Triiodothyronine (T3), Free Thyroxine (T4) done in the all cases and controls but anti-Thyroid Peroxidase (TPO), and anti-thyroglobulin antibody test was done in the case and control group with deranged thyroid function test. Low Free T4 (normal: 0.7-2 ng/mL) and elevated serum TSH above the upper limit of the reference range (>4.5 mIU/L) was defined as overt hypothyroidism, whereas elevation in serum TSH with a normal serum FT4 concentration was defined as sub clinical hypothyroidism. MedCalc statistical software Version 19.2.6 was used to do statistical analysis. Results: Prevalence of Non-autoimmune hypothyroidism was 38.46% (20 out of 52), 16 (30.76%) had subclinical and 4 (7.69%) had overt hypothyroidism in case of SRNS in comparison to 1.96% (1 out of 52) in control group. Out of 16 subclinical hypothyroid patients, two cases with grade 1, 12 cases with grade 2, and two cases with grade 3 found. Patients with SRNS had a mean (SD) TSH value of 4.5±4.7 mlU/L which was significantly higher than control (1.8±1.1 mlU/L). Serum levels of FT4 were within normal range. Anti-TPO and anti-thyroglobulin titre were in normal range in children with hypothyroidism. Conclusion: The prevalence of non-autoimmune hypothyroidism was high in cases of idiopathic SRNS. So, on the basis of this study estimation of thyroid profile in children with SRNS seems to be the rational approach which will lead to early diagnosis and timely management of hypothyroidism in SRNS.https://jcdr.net/articles/PDF/14077/45530_CE[Ra1]_F(KM)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_GC(RV_SL)_PN(SL).pdfanti-thyroid peroxidaseovertsubclinicalthyroid stimulating hormone |
| spellingShingle | Seema Rani Sinha Rekha Kumari Rakesh Kumar Ravi Shekhar Pritam Prakash Prem Prakash Prevalence of Non-autoimmune Hypothyroidism in Steroid Resistant Nephrotic Syndrome in Paediatric Age Group Journal of Clinical and Diagnostic Research anti-thyroid peroxidase overt subclinical thyroid stimulating hormone |
| title | Prevalence of Non-autoimmune Hypothyroidism in Steroid Resistant Nephrotic Syndrome in Paediatric Age Group |
| title_full | Prevalence of Non-autoimmune Hypothyroidism in Steroid Resistant Nephrotic Syndrome in Paediatric Age Group |
| title_fullStr | Prevalence of Non-autoimmune Hypothyroidism in Steroid Resistant Nephrotic Syndrome in Paediatric Age Group |
| title_full_unstemmed | Prevalence of Non-autoimmune Hypothyroidism in Steroid Resistant Nephrotic Syndrome in Paediatric Age Group |
| title_short | Prevalence of Non-autoimmune Hypothyroidism in Steroid Resistant Nephrotic Syndrome in Paediatric Age Group |
| title_sort | prevalence of non autoimmune hypothyroidism in steroid resistant nephrotic syndrome in paediatric age group |
| topic | anti-thyroid peroxidase overt subclinical thyroid stimulating hormone |
| url | https://jcdr.net/articles/PDF/14077/45530_CE[Ra1]_F(KM)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_GC(RV_SL)_PN(SL).pdf |
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