Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation
Nattokinase, a serine protease that originates from the traditional food natto, has garnered widespread attention due to its pharmacological functions and therapeutic potential. This review aims to delve into the major advancements of nattokinase across various domains, particularly its emerging rol...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
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| Series: | Fermentation |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-5637/9/11/950 |
| _version_ | 1797459407355772928 |
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| author | Mudannan Fang Beichen Yuan Meng Wang Junfeng Liu Zheng Wang |
| author_facet | Mudannan Fang Beichen Yuan Meng Wang Junfeng Liu Zheng Wang |
| author_sort | Mudannan Fang |
| collection | DOAJ |
| description | Nattokinase, a serine protease that originates from the traditional food natto, has garnered widespread attention due to its pharmacological functions and therapeutic potential. This review aims to delve into the major advancements of nattokinase across various domains, particularly its emerging roles in Alzheimer’s disease prevention and the treatment of retinal diseases, thereby seeking to usher in a newfound hope in the fields of neurology and ophthalmology. However, the production and preservation of nattokinase present a multitude of challenges, including issues of unstable yield and enzyme activity loss. To address these challenges, we explore potential solutions such as the heterologous expression of the nattokinase gene, the optimization of microbial fermentation strategies, and innovative purification methods. Furthermore, we focus on enhancing the stability and protection of nattokinase through encapsulation and immobilization techniques, thus ensuring its sustainability across a wide array of applications. This review provides readers with the opportunity to gain an in-depth understanding of the diverse prospects for nattokinase applications. Future research directions will encompass a deeper exploration of its biological mechanisms, the development of novel nattokinase derivatives, and the extension of its applications into a broader spectrum of disease treatments and health maintenance. |
| first_indexed | 2024-03-09T16:50:54Z |
| format | Article |
| id | doaj.art-7314ef2bee954ca9bf53d889867e0af4 |
| institution | Directory Open Access Journal |
| issn | 2311-5637 |
| language | English |
| last_indexed | 2024-03-09T16:50:54Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fermentation |
| spelling | doaj.art-7314ef2bee954ca9bf53d889867e0af42023-11-24T14:41:18ZengMDPI AGFermentation2311-56372023-11-0191195010.3390/fermentation9110950Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial FermentationMudannan Fang0Beichen Yuan1Meng Wang2Junfeng Liu3Zheng Wang4Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaSteel Research Engineering Design Co., Ltd., Beijing 100081, ChinaBeijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaBeijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaBeijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaNattokinase, a serine protease that originates from the traditional food natto, has garnered widespread attention due to its pharmacological functions and therapeutic potential. This review aims to delve into the major advancements of nattokinase across various domains, particularly its emerging roles in Alzheimer’s disease prevention and the treatment of retinal diseases, thereby seeking to usher in a newfound hope in the fields of neurology and ophthalmology. However, the production and preservation of nattokinase present a multitude of challenges, including issues of unstable yield and enzyme activity loss. To address these challenges, we explore potential solutions such as the heterologous expression of the nattokinase gene, the optimization of microbial fermentation strategies, and innovative purification methods. Furthermore, we focus on enhancing the stability and protection of nattokinase through encapsulation and immobilization techniques, thus ensuring its sustainability across a wide array of applications. This review provides readers with the opportunity to gain an in-depth understanding of the diverse prospects for nattokinase applications. Future research directions will encompass a deeper exploration of its biological mechanisms, the development of novel nattokinase derivatives, and the extension of its applications into a broader spectrum of disease treatments and health maintenance.https://www.mdpi.com/2311-5637/9/11/950nattokinasecardiovascular diseasedetection methodsoptimizing production |
| spellingShingle | Mudannan Fang Beichen Yuan Meng Wang Junfeng Liu Zheng Wang Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation Fermentation nattokinase cardiovascular disease detection methods optimizing production |
| title | Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation |
| title_full | Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation |
| title_fullStr | Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation |
| title_full_unstemmed | Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation |
| title_short | Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation |
| title_sort | nattokinase insights into biological activity therapeutic applications and the influence of microbial fermentation |
| topic | nattokinase cardiovascular disease detection methods optimizing production |
| url | https://www.mdpi.com/2311-5637/9/11/950 |
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