Development and research progress of anti-drug resistant fungal drugs
With the widespread use of immunosuppressive agents and the increase in patients with severe infections, the incidence of fungal infections worldwide has increased year by year. The fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus cause a total of more than 1 mill...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122002064 |
| _version_ | 1797999682175107072 |
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| author | Xiangyi Cui Lanlin Wang Yuhong Lü Changwu Yue |
| author_facet | Xiangyi Cui Lanlin Wang Yuhong Lü Changwu Yue |
| author_sort | Xiangyi Cui |
| collection | DOAJ |
| description | With the widespread use of immunosuppressive agents and the increase in patients with severe infections, the incidence of fungal infections worldwide has increased year by year. The fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus cause a total of more than 1 million deaths each year. Long-term use of antifungal drugs can easily lead to fungal resistance, and the prevalence of drug-resistant fungi is a major global health challenge. In order to effectively control global fungal infections, there is an urgent need for new drugs that can exert effective antifungal activity and overcome drug resistance. We must promote the discovery of new antifungal targets and drugs, and find effective ways to control drug-resistant fungi through different ways, so as to reduce the threat of drug-resistant fungi to human life, health and safety. In the past few years, certain progress has been made in the research and development of antifungal drugs. In addition to summarizing some of the antifungal drugs currently approved by the FDA, this review also focuses on potential antifungal drugs, the repositioned drugs, and drugs that can treat drug-resistant bacteria and fungal infections, and provide new ideas for the development of antifungal drugs in the future. |
| first_indexed | 2024-04-11T11:08:34Z |
| format | Article |
| id | doaj.art-73180903c6c2469db475e40004468407 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-11T11:08:34Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-73180903c6c2469db475e400044684072022-12-22T04:28:13ZengElsevierJournal of Infection and Public Health1876-03412022-09-011599861000Development and research progress of anti-drug resistant fungal drugsXiangyi Cui0Lanlin Wang1Yuhong Lü2Changwu Yue3Key Laboratory of Microbial Drugs Innovation and Transformation of Yan’an, School of Basic Medicine, Yan’an University, Yan’an 716000, Shaanxi, China; Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources,Yan'an University, NO.580 Shengdi Road, Baota District, Yan'an 716000, Shaanxi, ChinaKey Laboratory of Microbial Drugs Innovation and Transformation of Yan’an, School of Basic Medicine, Yan’an University, Yan’an 716000, Shaanxi, China; Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources,Yan'an University, NO.580 Shengdi Road, Baota District, Yan'an 716000, Shaanxi, ChinaKey Laboratory of Microbial Drugs Innovation and Transformation of Yan’an, School of Basic Medicine, Yan’an University, Yan’an 716000, Shaanxi, China; Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources,Yan'an University, NO.580 Shengdi Road, Baota District, Yan'an 716000, Shaanxi, China; Corresponding authors at: Key Laboratory of Microbial Drugs Innovation and Transformation of Yan’an, School of Basic Medicine, Yan’an University, Yan’an 716000, Shaanxi, China.Key Laboratory of Microbial Drugs Innovation and Transformation of Yan’an, School of Basic Medicine, Yan’an University, Yan’an 716000, Shaanxi, China; Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources,Yan'an University, NO.580 Shengdi Road, Baota District, Yan'an 716000, Shaanxi, China; Corresponding authors at: Key Laboratory of Microbial Drugs Innovation and Transformation of Yan’an, School of Basic Medicine, Yan’an University, Yan’an 716000, Shaanxi, China.With the widespread use of immunosuppressive agents and the increase in patients with severe infections, the incidence of fungal infections worldwide has increased year by year. The fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus cause a total of more than 1 million deaths each year. Long-term use of antifungal drugs can easily lead to fungal resistance, and the prevalence of drug-resistant fungi is a major global health challenge. In order to effectively control global fungal infections, there is an urgent need for new drugs that can exert effective antifungal activity and overcome drug resistance. We must promote the discovery of new antifungal targets and drugs, and find effective ways to control drug-resistant fungi through different ways, so as to reduce the threat of drug-resistant fungi to human life, health and safety. In the past few years, certain progress has been made in the research and development of antifungal drugs. In addition to summarizing some of the antifungal drugs currently approved by the FDA, this review also focuses on potential antifungal drugs, the repositioned drugs, and drugs that can treat drug-resistant bacteria and fungal infections, and provide new ideas for the development of antifungal drugs in the future.http://www.sciencedirect.com/science/article/pii/S1876034122002064Drug-resistant fungiFungal infectionsAntifungalsAntibioticsAntifungal drug development |
| spellingShingle | Xiangyi Cui Lanlin Wang Yuhong Lü Changwu Yue Development and research progress of anti-drug resistant fungal drugs Journal of Infection and Public Health Drug-resistant fungi Fungal infections Antifungals Antibiotics Antifungal drug development |
| title | Development and research progress of anti-drug resistant fungal drugs |
| title_full | Development and research progress of anti-drug resistant fungal drugs |
| title_fullStr | Development and research progress of anti-drug resistant fungal drugs |
| title_full_unstemmed | Development and research progress of anti-drug resistant fungal drugs |
| title_short | Development and research progress of anti-drug resistant fungal drugs |
| title_sort | development and research progress of anti drug resistant fungal drugs |
| topic | Drug-resistant fungi Fungal infections Antifungals Antibiotics Antifungal drug development |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122002064 |
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