Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review
Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side eff...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/58/3/430 |
| _version_ | 1797445272964431872 |
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| author | Ioannis Ilias Manfredi Rizzo Lina Zabuliene |
| author_facet | Ioannis Ilias Manfredi Rizzo Lina Zabuliene |
| author_sort | Ioannis Ilias |
| collection | DOAJ |
| description | Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. Despite some promising results with MTF regarding pregnancy rates in women with PCOS, the management of gestational diabetes, cancer prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses have yet to confirm such beneficial effects. |
| first_indexed | 2024-03-09T13:23:24Z |
| format | Article |
| id | doaj.art-73183b699b644697b3aa4c6073f7cce1 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T13:23:24Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-73183b699b644697b3aa4c6073f7cce12023-11-30T21:26:53ZengMDPI AGMedicina1010-660X1648-91442022-03-0158343010.3390/medicina58030430Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative ReviewIoannis Ilias0Manfredi Rizzo1Lina Zabuliene2Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, GR-11521 Athens, GreeceDepartment of Health Promotion Sciences, Maternal and Infantile Care, Internal Medicine and Medical Specialties (Promise), School of Medicine, University of Palermo, Via del Vespro, 141, 90127 Palermo, ItalyFaculty of Medicine, Vilnius University, M. K. Čiurlionio St. 21/27, LT-03101 Vilnius, LithuaniaMetformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. Despite some promising results with MTF regarding pregnancy rates in women with PCOS, the management of gestational diabetes, cancer prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses have yet to confirm such beneficial effects.https://www.mdpi.com/1648-9144/58/3/430Metformingenderinsulin resistance |
| spellingShingle | Ioannis Ilias Manfredi Rizzo Lina Zabuliene Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review Medicina Metformin gender insulin resistance |
| title | Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review |
| title_full | Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review |
| title_fullStr | Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review |
| title_full_unstemmed | Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review |
| title_short | Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review |
| title_sort | metformin sex gender differences in its uses and effects narrative review |
| topic | Metformin gender insulin resistance |
| url | https://www.mdpi.com/1648-9144/58/3/430 |
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