Analgesic effects of intra-articular ropivacaine following arthroscopic knee surgery: Results of a double-blind, randomized controlled trial between two different doses
Background: Though local anesthetic agents are widely used to provide postoperative analgesia in intra-articular route, their efficacy is not accepted universally. Objective: The present study has been conducted to compare the analgesic effects of intra-articular ropivacaine between two different...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2014-07-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/9703 |
| _version_ | 1828822044674883584 |
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| author | Rajdip Hazra |
| author_facet | Rajdip Hazra |
| author_sort | Rajdip Hazra |
| collection | DOAJ |
| description | Background: Though local anesthetic agents are widely used to provide postoperative analgesia in intra-articular route, their efficacy is not accepted universally.
Objective: The present study has been conducted to compare the analgesic effects of intra-articular ropivacaine between two different doses following arthroscopic knee surgery.
Study design: Double-blinded randomized controlled trial. Total 60 patients of ASA (American Society of Anesthesiologists) physical status I and II, 34 male and 26 female, aged between 18 to 60 years, were randomized into 3 groups receiving 10 ml normal saline, 10 ml 0.5% ropivacaine and 10 ml 0.75% ropivacaine respectively, administered in intra-articular space at the end of operation.
Results: Ropivacaine groups had significantly delayed first post-operative rescue analgesic request with significantly lesser requirement of rescue analgesia in first 24 hours (p<0.001 in both cases). Except 6th post-operative hours, ropivacaine groups also showed significantly less VAS scores (Visual Analogue Scale) up to 12 hours post-operatively (p<0.05).
Conclusion: In our double-blinded randomized controlled trial, administration of intra-articular 0.75% ropivacaine showed superior analgesic efficacy following arthroscopic knee surgery. Further, larger trials are needed to confirm our findings. |
| first_indexed | 2024-12-12T13:06:29Z |
| format | Article |
| id | doaj.art-73190d65d3694f77849e94cec133d821 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-12T13:06:29Z |
| publishDate | 2014-07-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-73190d65d3694f77849e94cec133d8212022-12-22T00:23:38ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762014-07-01618186https://doi.org/10.3126/ajms.v6i1.9703Analgesic effects of intra-articular ropivacaine following arthroscopic knee surgery: Results of a double-blind, randomized controlled trial between two different dosesRajdip Hazra 0Department of Anesthesiology, Nilratan Sircar Medical College and Hospital, KolkataBackground: Though local anesthetic agents are widely used to provide postoperative analgesia in intra-articular route, their efficacy is not accepted universally. Objective: The present study has been conducted to compare the analgesic effects of intra-articular ropivacaine between two different doses following arthroscopic knee surgery. Study design: Double-blinded randomized controlled trial. Total 60 patients of ASA (American Society of Anesthesiologists) physical status I and II, 34 male and 26 female, aged between 18 to 60 years, were randomized into 3 groups receiving 10 ml normal saline, 10 ml 0.5% ropivacaine and 10 ml 0.75% ropivacaine respectively, administered in intra-articular space at the end of operation. Results: Ropivacaine groups had significantly delayed first post-operative rescue analgesic request with significantly lesser requirement of rescue analgesia in first 24 hours (p<0.001 in both cases). Except 6th post-operative hours, ropivacaine groups also showed significantly less VAS scores (Visual Analogue Scale) up to 12 hours post-operatively (p<0.05). Conclusion: In our double-blinded randomized controlled trial, administration of intra-articular 0.75% ropivacaine showed superior analgesic efficacy following arthroscopic knee surgery. Further, larger trials are needed to confirm our findings.https://www.nepjol.info/index.php/AJMS/article/view/9703ropivacainefentanyldexmedetomidineanalgesiaintra-articular routearthroscopic knee surgery |
| spellingShingle | Rajdip Hazra Analgesic effects of intra-articular ropivacaine following arthroscopic knee surgery: Results of a double-blind, randomized controlled trial between two different doses Asian Journal of Medical Sciences ropivacaine fentanyl dexmedetomidine analgesia intra-articular route arthroscopic knee surgery |
| title | Analgesic effects of intra-articular ropivacaine following arthroscopic knee surgery: Results of a double-blind, randomized controlled trial between two different doses |
| title_full | Analgesic effects of intra-articular ropivacaine following arthroscopic knee surgery: Results of a double-blind, randomized controlled trial between two different doses |
| title_fullStr | Analgesic effects of intra-articular ropivacaine following arthroscopic knee surgery: Results of a double-blind, randomized controlled trial between two different doses |
| title_full_unstemmed | Analgesic effects of intra-articular ropivacaine following arthroscopic knee surgery: Results of a double-blind, randomized controlled trial between two different doses |
| title_short | Analgesic effects of intra-articular ropivacaine following arthroscopic knee surgery: Results of a double-blind, randomized controlled trial between two different doses |
| title_sort | analgesic effects of intra articular ropivacaine following arthroscopic knee surgery results of a double blind randomized controlled trial between two different doses |
| topic | ropivacaine fentanyl dexmedetomidine analgesia intra-articular route arthroscopic knee surgery |
| url | https://www.nepjol.info/index.php/AJMS/article/view/9703 |
| work_keys_str_mv | AT rajdiphazra analgesiceffectsofintraarticularropivacainefollowingarthroscopickneesurgeryresultsofadoubleblindrandomizedcontrolledtrialbetweentwodifferentdoses |