OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1

OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1

Cancer cells develop protective adaptations against oxidative DNA damage, providing a strong rationale for targeting DNA repair proteins. There has been a high degree of recent interest in inhibiting the mammalian Nudix pyrophosphatase MutT Homolog 1 (MTH1). MTH1 degrades 8-oxo-dGTP, thus limiting i...

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Bibliographic Details
Main Authors: Ling Zhang, Laura Misiara, Govindi J. Samaranayake, Nisha Sharma, Dao M. Nguyen, Yu-Ki Tahara, Eric T. Kool, Priyamvada Rai
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Redox Biology
Subjects:
OGG1 inhibition
MTH1 inhibition
oxidative DNA damage
lung cancer
p53
senescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720310533

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