Camellia oil alleviates DSS-induced colitis in mice by regulating the abundance of intestinal flora and suppressing the NF-κB signaling pathway
Colitis is characterized by colonic inflammation and impaired gut health, and alterations in the gut microbiota may lead to the development of inflammatory bowel disease (IBD). Camellia oil (CO) possesses high nutritional value and offers various health benefits for human metabolic disorders and dis...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623003778 |
| _version_ | 1797688968795389952 |
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| author | Qihong Jiang Chenkai Jiang Hongling Lu Tianyi Zhou Wenjun Hu Chin Ping Tan Yongcai Feng Guoxin Shen Xingwei Xiang Lin Chen |
| author_facet | Qihong Jiang Chenkai Jiang Hongling Lu Tianyi Zhou Wenjun Hu Chin Ping Tan Yongcai Feng Guoxin Shen Xingwei Xiang Lin Chen |
| author_sort | Qihong Jiang |
| collection | DOAJ |
| description | Colitis is characterized by colonic inflammation and impaired gut health, and alterations in the gut microbiota may lead to the development of inflammatory bowel disease (IBD). Camellia oil (CO) possesses high nutritional value and offers various health benefits for human metabolic disorders and diseases. However, it is unclear whether CO ameliorates IBD and plays a role in the gut microbiota. This study aimed to investigate the effect of CO on colonic inflammation and gut microbiota using a mice model of dextran sodium sulfate (Dss)-induced ulcerative colitis (UC). Our findings demonstrated that CO inhibited weight loss and colon shortening and improved intestinal barrier function. Additionally, CO treatment reduced oxidative stress and inflammatory responses in Dss-induced colitis. Furthermore, CO significantly inhibited p65 and IκBα phosphorylation and alleviated colonic inflammation. Moreover, we observed that CO treatment increased the abundance of Bacteroides, Lactobacillus, and Odoribacter, while decreasing the abundance of Alistipes, Lachnospiraceae NK4A136 group, Ruminococcaceae UCG-014, uncultured Bacteroidales bacterium, and Prevotellaceae_UCG-001. Additionally, CO treatment promoted the production of SCFAs. These data indicated the promising potential of CO to prevent UC by maintaining gut barrier function, inhibiting the NF-κB signaling pathway, and modulating the gut microbiota. |
| first_indexed | 2024-03-12T01:38:13Z |
| format | Article |
| id | doaj.art-731b4f7b2657498fb247ed18a33eb1c8 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T01:38:13Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-731b4f7b2657498fb247ed18a33eb1c82023-09-11T04:16:58ZengElsevierJournal of Functional Foods1756-46462023-09-01108105777Camellia oil alleviates DSS-induced colitis in mice by regulating the abundance of intestinal flora and suppressing the NF-κB signaling pathwayQihong Jiang0Chenkai Jiang1Hongling Lu2Tianyi Zhou3Wenjun Hu4Chin Ping Tan5Yongcai Feng6Guoxin Shen7Xingwei Xiang8Lin Chen9Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, China; Xujing (Hangzhou) Biotechnology Research Institute Co., Ltd., Hangzhou, Zhejiang 310021, ChinaInstitute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, ChinaInstitute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, ChinaInstitute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, ChinaInstitute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, ChinaXujing (Hangzhou) Biotechnology Research Institute Co., Ltd., Hangzhou, Zhejiang 310021, China; Department of Food Technology, Faculty of Food Science and Technology, University Putra Malaysia, 43400 Serdang, MalaysiaXujing (Hangzhou) Biotechnology Research Institute Co., Ltd., Hangzhou, Zhejiang 310021, ChinaInstitute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, ChinaCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China; Corresponding author.Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, China; Corresponding author.Colitis is characterized by colonic inflammation and impaired gut health, and alterations in the gut microbiota may lead to the development of inflammatory bowel disease (IBD). Camellia oil (CO) possesses high nutritional value and offers various health benefits for human metabolic disorders and diseases. However, it is unclear whether CO ameliorates IBD and plays a role in the gut microbiota. This study aimed to investigate the effect of CO on colonic inflammation and gut microbiota using a mice model of dextran sodium sulfate (Dss)-induced ulcerative colitis (UC). Our findings demonstrated that CO inhibited weight loss and colon shortening and improved intestinal barrier function. Additionally, CO treatment reduced oxidative stress and inflammatory responses in Dss-induced colitis. Furthermore, CO significantly inhibited p65 and IκBα phosphorylation and alleviated colonic inflammation. Moreover, we observed that CO treatment increased the abundance of Bacteroides, Lactobacillus, and Odoribacter, while decreasing the abundance of Alistipes, Lachnospiraceae NK4A136 group, Ruminococcaceae UCG-014, uncultured Bacteroidales bacterium, and Prevotellaceae_UCG-001. Additionally, CO treatment promoted the production of SCFAs. These data indicated the promising potential of CO to prevent UC by maintaining gut barrier function, inhibiting the NF-κB signaling pathway, and modulating the gut microbiota.http://www.sciencedirect.com/science/article/pii/S1756464623003778Camellia oilUlcerative colitisIntestinal permeabilityNF-κB signaling pathwayGut microbiota |
| spellingShingle | Qihong Jiang Chenkai Jiang Hongling Lu Tianyi Zhou Wenjun Hu Chin Ping Tan Yongcai Feng Guoxin Shen Xingwei Xiang Lin Chen Camellia oil alleviates DSS-induced colitis in mice by regulating the abundance of intestinal flora and suppressing the NF-κB signaling pathway Journal of Functional Foods Camellia oil Ulcerative colitis Intestinal permeability NF-κB signaling pathway Gut microbiota |
| title | Camellia oil alleviates DSS-induced colitis in mice by regulating the abundance of intestinal flora and suppressing the NF-κB signaling pathway |
| title_full | Camellia oil alleviates DSS-induced colitis in mice by regulating the abundance of intestinal flora and suppressing the NF-κB signaling pathway |
| title_fullStr | Camellia oil alleviates DSS-induced colitis in mice by regulating the abundance of intestinal flora and suppressing the NF-κB signaling pathway |
| title_full_unstemmed | Camellia oil alleviates DSS-induced colitis in mice by regulating the abundance of intestinal flora and suppressing the NF-κB signaling pathway |
| title_short | Camellia oil alleviates DSS-induced colitis in mice by regulating the abundance of intestinal flora and suppressing the NF-κB signaling pathway |
| title_sort | camellia oil alleviates dss induced colitis in mice by regulating the abundance of intestinal flora and suppressing the nf κb signaling pathway |
| topic | Camellia oil Ulcerative colitis Intestinal permeability NF-κB signaling pathway Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623003778 |
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