Single mutations in BraRS confer high resistance against nisin A in Staphylococcus aureus

Single mutations in BraRS confer high resistance against nisin A in Staphylococcus aureus

Abstract Nisin A is a lantibiotic produced by Lactococcus lactis that is widely used as a food preservative. In Staphylococcus aureus, the BraRS two‐component system (TCS) senses nisin A and regulates the expression of the ABC transporter VraDE, which is responsible for nisin A resistance. In this s...

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Bibliographic Details
Main Authors: Kaoru Arii, Miki Kawada‐Matsuo, Yuichi Oogai, Kazuyuki Noguchi, Hitoshi Komatsuzawa
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:MicrobiologyOpen
Subjects:
ABC transporter
mutation
nisin A
resistance
two‐component system
Online Access:https://doi.org/10.1002/mbo3.791

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