Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode
Abstract The traditional method of monitoring the oxidation and reduction of biomedical materials usually relies on electrochemical (EC) measurement techniques. Here, we demonstrate a surface plasmon resonance (SPR) method to monitor the oxidation process. Using levodopa L-dopa as the target analyte...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2023-11-01
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| Series: | Discover Nano |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11671-023-03930-5 |
| _version_ | 1827602983785857024 |
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| author | Hao-Fang Peng Chih-Kang Chang Rohit Gupta Jian-Jang Huang |
| author_facet | Hao-Fang Peng Chih-Kang Chang Rohit Gupta Jian-Jang Huang |
| author_sort | Hao-Fang Peng |
| collection | DOAJ |
| description | Abstract The traditional method of monitoring the oxidation and reduction of biomedical materials usually relies on electrochemical (EC) measurement techniques. Here, we demonstrate a surface plasmon resonance (SPR) method to monitor the oxidation process. Using levodopa L-dopa as the target analyte, a nanohole sensing plate is embedded in the EC electrode to enhance the oxidation signal and generate SPR. Cyclic voltammetry (CV) measurement was first conducted to understand the baseline of EC response of L-Dopa. Then, the redox reactions were simultaneously monitored through SPR measurements during the CV voltage scan. The results showed that the limit of detection using traditional CV reached 1.47 μM while using EC-SPR, the limit of detection improved to 1.23 μM. Most importantly, we found a strong correlation between CV current profiles and the SPR reflection spectra. Our results facilitate detecting electrochemical reactions using an optical probing method. |
| first_indexed | 2024-03-09T05:30:16Z |
| format | Article |
| id | doaj.art-731dae7692e84559950dbcc01d23c883 |
| institution | Directory Open Access Journal |
| issn | 2731-9229 |
| language | English |
| last_indexed | 2024-03-09T05:30:16Z |
| publishDate | 2023-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Nano |
| spelling | doaj.art-731dae7692e84559950dbcc01d23c8832023-12-03T12:33:33ZengSpringerDiscover Nano2731-92292023-11-011811910.1186/s11671-023-03930-5Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrodeHao-Fang Peng0Chih-Kang Chang1Rohit Gupta2Jian-Jang Huang3Graduate Institute of Photonics and Optoelectronics, National Taiwan UniversityGraduate Institute of Photonics and Optoelectronics, National Taiwan UniversityGraduate Institute of Photonics and Optoelectronics, National Taiwan UniversityGraduate Institute of Photonics and Optoelectronics, National Taiwan UniversityAbstract The traditional method of monitoring the oxidation and reduction of biomedical materials usually relies on electrochemical (EC) measurement techniques. Here, we demonstrate a surface plasmon resonance (SPR) method to monitor the oxidation process. Using levodopa L-dopa as the target analyte, a nanohole sensing plate is embedded in the EC electrode to enhance the oxidation signal and generate SPR. Cyclic voltammetry (CV) measurement was first conducted to understand the baseline of EC response of L-Dopa. Then, the redox reactions were simultaneously monitored through SPR measurements during the CV voltage scan. The results showed that the limit of detection using traditional CV reached 1.47 μM while using EC-SPR, the limit of detection improved to 1.23 μM. Most importantly, we found a strong correlation between CV current profiles and the SPR reflection spectra. Our results facilitate detecting electrochemical reactions using an optical probing method.https://doi.org/10.1186/s11671-023-03930-5Surface plasmon resonanceNanoholes arrayBiosensorCyclic voltammetryL-Dopa |
| spellingShingle | Hao-Fang Peng Chih-Kang Chang Rohit Gupta Jian-Jang Huang Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode Discover Nano Surface plasmon resonance Nanoholes array Biosensor Cyclic voltammetry L-Dopa |
| title | Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode |
| title_full | Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode |
| title_fullStr | Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode |
| title_full_unstemmed | Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode |
| title_short | Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode |
| title_sort | monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode |
| topic | Surface plasmon resonance Nanoholes array Biosensor Cyclic voltammetry L-Dopa |
| url | https://doi.org/10.1186/s11671-023-03930-5 |
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