Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection
Herpes simplex virus 1 (HSV-1) is a widely distributed virus. HSV-1 is a growing public health concern due to the emergence of drug-resistant strains and the current lack of a clinically specific drug for treatment. In recent years, increasing attention has been paid to the development of peptide an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1201505/full |
| _version_ | 1797772660021657600 |
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| author | Xiaomin Guo Yanxing An Wanmin Tan Ling Ma Mingyang Wang Juyan Li Binghong Li Wei Hou Li Wu |
| author_facet | Xiaomin Guo Yanxing An Wanmin Tan Ling Ma Mingyang Wang Juyan Li Binghong Li Wei Hou Li Wu |
| author_sort | Xiaomin Guo |
| collection | DOAJ |
| description | Herpes simplex virus 1 (HSV-1) is a widely distributed virus. HSV-1 is a growing public health concern due to the emergence of drug-resistant strains and the current lack of a clinically specific drug for treatment. In recent years, increasing attention has been paid to the development of peptide antivirals. Natural host-defense peptides which have uniquely evolved to protect the host have been reported to have antiviral properties. Cathelicidins are a family of multi-functional antimicrobial peptides found in almost all vertebrate species and play a vital role in the immune system. In this study, we demonstrated the anti-HSV-1 effect of an antiviral peptide named WL-1 derived from human cathelicidin. We found that WL-1 inhibited HSV-1 infection in epithelial and neuronal cells. Furthermore, the administration of WL-1 improved the survival rate and reduced viral load and inflammation during HSV-1 infection via ocular scarification. Moreover, facial nerve dysfunction, involving the abnormal blink reflex, nose position, and vibrissae movement, and pathological injury were prevented when HSV-1 ear inoculation-infected mice were treated with WL-1. Together, our findings demonstrate that WL-1 may be a potential novel antiviral agent against HSV-1 infection-induced facial palsy. |
| first_indexed | 2024-03-12T21:55:10Z |
| format | Article |
| id | doaj.art-731e4e44841145cebda99ef79c4d6fd6 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-12T21:55:10Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-731e4e44841145cebda99ef79c4d6fd62023-07-25T18:02:50ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-06-011410.3389/fmicb.2023.12015051201505Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infectionXiaomin Guo0Yanxing An1Wanmin Tan2Ling Ma3Mingyang Wang4Juyan Li5Binghong Li6Wei Hou7Li Wu8College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, ChinaDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, ChinaDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaHerpes simplex virus 1 (HSV-1) is a widely distributed virus. HSV-1 is a growing public health concern due to the emergence of drug-resistant strains and the current lack of a clinically specific drug for treatment. In recent years, increasing attention has been paid to the development of peptide antivirals. Natural host-defense peptides which have uniquely evolved to protect the host have been reported to have antiviral properties. Cathelicidins are a family of multi-functional antimicrobial peptides found in almost all vertebrate species and play a vital role in the immune system. In this study, we demonstrated the anti-HSV-1 effect of an antiviral peptide named WL-1 derived from human cathelicidin. We found that WL-1 inhibited HSV-1 infection in epithelial and neuronal cells. Furthermore, the administration of WL-1 improved the survival rate and reduced viral load and inflammation during HSV-1 infection via ocular scarification. Moreover, facial nerve dysfunction, involving the abnormal blink reflex, nose position, and vibrissae movement, and pathological injury were prevented when HSV-1 ear inoculation-infected mice were treated with WL-1. Together, our findings demonstrate that WL-1 may be a potential novel antiviral agent against HSV-1 infection-induced facial palsy.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1201505/fullcathelicidinsantiviral peptideHSV-1facial palsyWL-1 |
| spellingShingle | Xiaomin Guo Yanxing An Wanmin Tan Ling Ma Mingyang Wang Juyan Li Binghong Li Wei Hou Li Wu Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection Frontiers in Microbiology cathelicidins antiviral peptide HSV-1 facial palsy WL-1 |
| title | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
| title_full | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
| title_fullStr | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
| title_full_unstemmed | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
| title_short | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
| title_sort | cathelicidin derived antiviral peptide inhibits herpes simplex virus 1 infection |
| topic | cathelicidins antiviral peptide HSV-1 facial palsy WL-1 |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1201505/full |
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