Hispolon Methyl Ether, a Hispolon Analog, Suppresses the SRC/STAT3/Survivin Signaling Axis to Induce Cytotoxicity in Human Urinary Bladder Transitional Carcinoma Cell Lines

Hispolon Methyl Ether, a Hispolon Analog, Suppresses the SRC/STAT3/Survivin Signaling Axis to Induce Cytotoxicity in Human Urinary Bladder Transitional Carcinoma Cell Lines

Bladder cancer is a leading human malignancy worldwide. Signal transducer and activator of transcription (STAT) 3 is an oncogenic transcription factor commonly hyperactivated in most human cancers, including bladder cancer. Notably, preclinical evidence has validated STAT3 blockade as a promising th...

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Bibliographic Details
Main Authors: Min-Yung Kuo, Wei-Ting Yang, Yann-Jen Ho, Ge-Man Chang, Hsiung-Hao Chang, Chao-Yu Hsu, Chia-Che Chang, Yi-Hsin Chen
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
hispolon methyl ether
STAT3
SRC
survivin
apoptosis
bladder cancer
Online Access:https://www.mdpi.com/1422-0067/24/1/138

Internet

https://www.mdpi.com/1422-0067/24/1/138

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