Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1)
AimThe prevalence of latent tuberculosis infection (LTBI) among diabetes patients is poorly studied. In the present study, the prevalence of LTBI among pre-diabetes and diabetes patients was studied, along with immunoendocrine biomarkers (n = 804).MethodsLTBI was screened by Quantiferon TB gold in N...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.884374/full |
| _version_ | 1818545393657446400 |
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| author | Vivekanandhan Aravindhan Anup Bobhate Kuppan Sathishkumar Aruna Patil Satyavani Kumpatla Vijay Viswanathan |
| author_facet | Vivekanandhan Aravindhan Anup Bobhate Kuppan Sathishkumar Aruna Patil Satyavani Kumpatla Vijay Viswanathan |
| author_sort | Vivekanandhan Aravindhan |
| collection | DOAJ |
| description | AimThe prevalence of latent tuberculosis infection (LTBI) among diabetes patients is poorly studied. In the present study, the prevalence of LTBI among pre-diabetes and diabetes patients was studied, along with immunoendocrine biomarkers (n = 804).MethodsLTBI was screened by Quantiferon TB gold in Normal glucose tolerance [(NGT); n = 170, [Pre-diabetes (PDM; n = 209), Newly diagnosed diabetes (NDM; n = 165) and Known diabetes (KDM; n = 260) subjects. CRP, TNF-α, IL-6, IL-1β, IFN-β, IL-12, IFN-γ, IL-2, insulin, leptin, and adiponectin levels in serum and IFN-γ levels in quantiferon supernatants were quantified by ELISA. The expression of T-bet was quantified using qRT-PCR. Serum TBARS and nitrite levels were quantified by colorimetry.ResultsThe LTBI prevalence was 32% in NGT, 23% in PDM, 24% in NDM, and 32% in KDM groups, with an adjusted OR of 0.61 (p < 0.05). Downregulation of CRP, TNF-α, and nitrites and upregulation of adiponectin could be responsible for LTBI mediated protection against insulin resistance (IR), while the high levels of IL-1β, IL-12, and leptin could be responsible for IR mediated anti-TB immunity. The defective antigen-specific IFN-γ response, as seen in the KDM group, could be responsible for the low detection rate of LTBI and high probability of endogenous reactivation.ConclusionThere appears to be a biphasic relationship between diabetes-latent tuberculosis: At the early stages of diabetes it is reciprocal, while at a late stage it is synergistic, this important phenomenon obviously needs further research. |
| first_indexed | 2024-12-12T07:39:41Z |
| format | Article |
| id | doaj.art-73220d4f422342ff9bcd39a402ad184d |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T07:39:41Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-73220d4f422342ff9bcd39a402ad184d2022-12-22T00:32:50ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-06-011310.3389/fmicb.2022.884374884374Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1)Vivekanandhan Aravindhan0Anup Bobhate1Kuppan Sathishkumar2Aruna Patil3Satyavani Kumpatla4Vijay Viswanathan5Department of Genetics, Dr. ALM PG IBMS, University of Madras, Chennai, IndiaProf. M. Viswanathan Diabetes Research Centre, Chennai, IndiaDepartment of Genetics, Dr. ALM PG IBMS, University of Madras, Chennai, IndiaESIC-PGIMSR Medical College and Hospital, Chennai, IndiaProf. M. Viswanathan Diabetes Research Centre, Chennai, IndiaProf. M. Viswanathan Diabetes Research Centre, Chennai, IndiaAimThe prevalence of latent tuberculosis infection (LTBI) among diabetes patients is poorly studied. In the present study, the prevalence of LTBI among pre-diabetes and diabetes patients was studied, along with immunoendocrine biomarkers (n = 804).MethodsLTBI was screened by Quantiferon TB gold in Normal glucose tolerance [(NGT); n = 170, [Pre-diabetes (PDM; n = 209), Newly diagnosed diabetes (NDM; n = 165) and Known diabetes (KDM; n = 260) subjects. CRP, TNF-α, IL-6, IL-1β, IFN-β, IL-12, IFN-γ, IL-2, insulin, leptin, and adiponectin levels in serum and IFN-γ levels in quantiferon supernatants were quantified by ELISA. The expression of T-bet was quantified using qRT-PCR. Serum TBARS and nitrite levels were quantified by colorimetry.ResultsThe LTBI prevalence was 32% in NGT, 23% in PDM, 24% in NDM, and 32% in KDM groups, with an adjusted OR of 0.61 (p < 0.05). Downregulation of CRP, TNF-α, and nitrites and upregulation of adiponectin could be responsible for LTBI mediated protection against insulin resistance (IR), while the high levels of IL-1β, IL-12, and leptin could be responsible for IR mediated anti-TB immunity. The defective antigen-specific IFN-γ response, as seen in the KDM group, could be responsible for the low detection rate of LTBI and high probability of endogenous reactivation.ConclusionThere appears to be a biphasic relationship between diabetes-latent tuberculosis: At the early stages of diabetes it is reciprocal, while at a late stage it is synergistic, this important phenomenon obviously needs further research.https://www.frontiersin.org/articles/10.3389/fmicb.2022.884374/fulldiabeteshypertensioninflammationquantiferoncytokineslatent tuberculosis infection |
| spellingShingle | Vivekanandhan Aravindhan Anup Bobhate Kuppan Sathishkumar Aruna Patil Satyavani Kumpatla Vijay Viswanathan Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1) Frontiers in Microbiology diabetes hypertension inflammation quantiferon cytokines latent tuberculosis infection |
| title | Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1) |
| title_full | Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1) |
| title_fullStr | Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1) |
| title_full_unstemmed | Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1) |
| title_short | Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1) |
| title_sort | unique reciprocal association seen between latent tuberculosis infection and diabetes is due to immunoendocrine modulation dm ltb 1 |
| topic | diabetes hypertension inflammation quantiferon cytokines latent tuberculosis infection |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.884374/full |
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