Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study
<i>Background</i>: Left ventricular non-compaction (LVNC) is a rare cardiomyopathy typically involving the left ventricle (LV); however, the right ventricle (RV) can also be affected. This case-control study aimed to assess the morphology and function of LV and RV in children with LVNC....
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MDPI AG
2022-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/4/1104 |
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| author | Jędrzej Sarnecki Agata Paszkowska Joanna Petryka-Mazurkiewicz Agata Kubik Janusz Feber Elżbieta Jurkiewicz Lidia Ziółkowska |
| author_facet | Jędrzej Sarnecki Agata Paszkowska Joanna Petryka-Mazurkiewicz Agata Kubik Janusz Feber Elżbieta Jurkiewicz Lidia Ziółkowska |
| author_sort | Jędrzej Sarnecki |
| collection | DOAJ |
| description | <i>Background</i>: Left ventricular non-compaction (LVNC) is a rare cardiomyopathy typically involving the left ventricle (LV); however, the right ventricle (RV) can also be affected. This case-control study aimed to assess the morphology and function of LV and RV in children with LVNC. <i>Methods</i>: Sixteen children (13 ± 3 years, six girls) with LVNC were compared with 16 sex- and age-matched controls. LV and RV morphology and function were evaluated in cardiovascular magnetic resonance (CMR) studies. Additionally, LV and RV global radial (GRS), circumferential (GCS), and longitudinal strain (GLS) were assessed using tissue-tracking analysis. <i>Results</i>: Patients with LVNC did not differ from the healthy controls in terms of age, height, weight, and body surface area (BSA). In total, 4/16 subjects with LVNC had mid-wall late gadolinium enhancement (LGE). Compared to the control group, patients with LVNC had higher end-diastolic volume (EDV) indexed for body surface area (BSA), lower ejection fraction (EF), and lower LV strain parameters (all <i>p</i> < 0.05). Children with LVNC also presented with thicker RV apical trabeculation, whereas there were no differences in RV EF and EDV/BSA between the groups. Nevertheless, children with LVNC had impaired RV GRS and GCS (both <i>p</i> < 0.05). <i>Conclusions</i>: LVNC in pediatric patients is associated with LV enlargement and impaired LV systolic function. Additionally, children with LVNC have increased RV trabeculations and subclinical impairment of RV myocardial deformation. |
| first_indexed | 2024-03-09T21:41:04Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:41:04Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-7322e6521401440cb0c2c13f74c8fc382023-11-23T20:31:46ZengMDPI AGJournal of Clinical Medicine2077-03832022-02-01114110410.3390/jcm11041104Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance StudyJędrzej Sarnecki0Agata Paszkowska1Joanna Petryka-Mazurkiewicz2Agata Kubik3Janusz Feber4Elżbieta Jurkiewicz5Lidia Ziółkowska6Department of Diagnostic Imaging, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Cardiology, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Coronary and Structural Heart Diseases, National Institute of Cardiology, 04-628 Warsaw, PolandMagnetic Resonance Unit, National Institute of Cardiology, 04-628 Warsaw, PolandDivision of Nephrology, Children’s Hospital of East Ontario, University of Ottawa, Ottawa, ON K1H 8L1, CanadaDepartment of Diagnostic Imaging, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Cardiology, The Children’s Memorial Health Institute, 04-730 Warsaw, Poland<i>Background</i>: Left ventricular non-compaction (LVNC) is a rare cardiomyopathy typically involving the left ventricle (LV); however, the right ventricle (RV) can also be affected. This case-control study aimed to assess the morphology and function of LV and RV in children with LVNC. <i>Methods</i>: Sixteen children (13 ± 3 years, six girls) with LVNC were compared with 16 sex- and age-matched controls. LV and RV morphology and function were evaluated in cardiovascular magnetic resonance (CMR) studies. Additionally, LV and RV global radial (GRS), circumferential (GCS), and longitudinal strain (GLS) were assessed using tissue-tracking analysis. <i>Results</i>: Patients with LVNC did not differ from the healthy controls in terms of age, height, weight, and body surface area (BSA). In total, 4/16 subjects with LVNC had mid-wall late gadolinium enhancement (LGE). Compared to the control group, patients with LVNC had higher end-diastolic volume (EDV) indexed for body surface area (BSA), lower ejection fraction (EF), and lower LV strain parameters (all <i>p</i> < 0.05). Children with LVNC also presented with thicker RV apical trabeculation, whereas there were no differences in RV EF and EDV/BSA between the groups. Nevertheless, children with LVNC had impaired RV GRS and GCS (both <i>p</i> < 0.05). <i>Conclusions</i>: LVNC in pediatric patients is associated with LV enlargement and impaired LV systolic function. Additionally, children with LVNC have increased RV trabeculations and subclinical impairment of RV myocardial deformation.https://www.mdpi.com/2077-0383/11/4/1104left ventricular non-compactionchildrencardiovascular magnetic resonancestraintissue-trackinglate gadolinium enhancement |
| spellingShingle | Jędrzej Sarnecki Agata Paszkowska Joanna Petryka-Mazurkiewicz Agata Kubik Janusz Feber Elżbieta Jurkiewicz Lidia Ziółkowska Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study Journal of Clinical Medicine left ventricular non-compaction children cardiovascular magnetic resonance strain tissue-tracking late gadolinium enhancement |
| title | Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study |
| title_full | Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study |
| title_fullStr | Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study |
| title_full_unstemmed | Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study |
| title_short | Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study |
| title_sort | left and right ventricular morphology function and myocardial deformation in children with left ventricular non compaction cardiomyopathy a case control cardiovascular magnetic resonance study |
| topic | left ventricular non-compaction children cardiovascular magnetic resonance strain tissue-tracking late gadolinium enhancement |
| url | https://www.mdpi.com/2077-0383/11/4/1104 |
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