Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer
Pancreatic cancer (PC) poses significant clinical challenges, with late-stage diagnosis and limited therapeutic options contributing to its dismal prognosis. A hallmark feature of PC is the presence of a profoundly hypoxic tumour microenvironment, resulting from various factors such as fibrotic stro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/12/611 |
| _version_ | 1797381598326292480 |
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| author | Mutian Lian Maria Mortoglou Pinar Uysal-Onganer |
| author_facet | Mutian Lian Maria Mortoglou Pinar Uysal-Onganer |
| author_sort | Mutian Lian |
| collection | DOAJ |
| description | Pancreatic cancer (PC) poses significant clinical challenges, with late-stage diagnosis and limited therapeutic options contributing to its dismal prognosis. A hallmark feature of PC is the presence of a profoundly hypoxic tumour microenvironment, resulting from various factors such as fibrotic stroma, rapid tumour cell proliferation, and poor vascularization. Hypoxia plays a crucial role in promoting aggressive cancer behaviour, therapeutic resistance, and immunosuppression. Previous studies have explored the molecular mechanisms behind hypoxia-induced changes in PC, focusing on the role of hypoxia-inducible factors (HIFs). Among the myriad of molecules affected by hypoxia, microRNA-210 (miR-210) emerges as a central player. It is highly responsive to hypoxia and regulated by HIF-dependent and HIF-independent pathways. miR-210 influences critical cellular processes, including angiogenesis, metastasis, and apoptosis, all of which contribute to PC progression and resistance to treatment. Understanding these pathways provides insights into potential therapeutic targets. Furthermore, investigating the role of miR-210 and its regulation in hypoxia sheds light on the potential development of early diagnostic strategies, which are urgently needed to improve outcomes for PC patients. This review delves into the complexities of PC and introduces the roles of hypoxia and miR-210 in the progression of PC. |
| first_indexed | 2024-03-08T20:53:43Z |
| format | Article |
| id | doaj.art-73243caabad541d6a85a1bb35d03656a |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-08T20:53:43Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-73243caabad541d6a85a1bb35d03656a2023-12-22T14:00:40ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-12-0145129778979210.3390/cimb45120611Impact of Hypoxia-Induced miR-210 on Pancreatic CancerMutian Lian0Maria Mortoglou1Pinar Uysal-Onganer2Cancer Mechanisms and Biomarkers Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UKCancer Mechanisms and Biomarkers Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UKCancer Mechanisms and Biomarkers Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UKPancreatic cancer (PC) poses significant clinical challenges, with late-stage diagnosis and limited therapeutic options contributing to its dismal prognosis. A hallmark feature of PC is the presence of a profoundly hypoxic tumour microenvironment, resulting from various factors such as fibrotic stroma, rapid tumour cell proliferation, and poor vascularization. Hypoxia plays a crucial role in promoting aggressive cancer behaviour, therapeutic resistance, and immunosuppression. Previous studies have explored the molecular mechanisms behind hypoxia-induced changes in PC, focusing on the role of hypoxia-inducible factors (HIFs). Among the myriad of molecules affected by hypoxia, microRNA-210 (miR-210) emerges as a central player. It is highly responsive to hypoxia and regulated by HIF-dependent and HIF-independent pathways. miR-210 influences critical cellular processes, including angiogenesis, metastasis, and apoptosis, all of which contribute to PC progression and resistance to treatment. Understanding these pathways provides insights into potential therapeutic targets. Furthermore, investigating the role of miR-210 and its regulation in hypoxia sheds light on the potential development of early diagnostic strategies, which are urgently needed to improve outcomes for PC patients. This review delves into the complexities of PC and introduces the roles of hypoxia and miR-210 in the progression of PC.https://www.mdpi.com/1467-3045/45/12/611pancreatic cancerhypoxiaHIF-1αmicroRNA-210 |
| spellingShingle | Mutian Lian Maria Mortoglou Pinar Uysal-Onganer Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer Current Issues in Molecular Biology pancreatic cancer hypoxia HIF-1α microRNA-210 |
| title | Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer |
| title_full | Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer |
| title_fullStr | Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer |
| title_full_unstemmed | Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer |
| title_short | Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer |
| title_sort | impact of hypoxia induced mir 210 on pancreatic cancer |
| topic | pancreatic cancer hypoxia HIF-1α microRNA-210 |
| url | https://www.mdpi.com/1467-3045/45/12/611 |
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