A helicase-tethered ORC flip enables bidirectional helicase loading
Replication origins are licensed by loading two Mcm2-7 helicases around DNA in a head-to-head conformation poised to initiate bidirectional replication. This process requires origin–recognition complex (ORC), Cdc6, and Cdt1. Although different Cdc6 and Cdt1 molecules load each helicase, whether two...
Main Authors: | Shalini Gupta, Larry J Friedman, Jeff Gelles, Stephen P Bell |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/74282 |
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