The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.
To assess the efficacy and safety of propofol sedation for gastrointestinal endoscopy, we conducted a meta-analysis of randomized controlled trials (RCTs) comparing propofol with traditional sedative agents.RCTs comparing the effects of propofol and traditional sedative agents during gastrointestina...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3540096?pdf=render |
| _version_ | 1829101502666375168 |
|---|---|
| author | Daorong Wang Chaowu Chen Jie Chen Yaxiang Xu Lu Wang Zhen Zhu Denghao Deng Juan Chen Aihua Long Dong Tang Jun Liu |
| author_facet | Daorong Wang Chaowu Chen Jie Chen Yaxiang Xu Lu Wang Zhen Zhu Denghao Deng Juan Chen Aihua Long Dong Tang Jun Liu |
| author_sort | Daorong Wang |
| collection | DOAJ |
| description | To assess the efficacy and safety of propofol sedation for gastrointestinal endoscopy, we conducted a meta-analysis of randomized controlled trials (RCTs) comparing propofol with traditional sedative agents.RCTs comparing the effects of propofol and traditional sedative agents during gastrointestinal endoscopy were found on MEDLINE, the Cochrane Central Register of Controlled Trials, and EMBASE. Cardiopulmonary complications (i.e., hypoxia, hypotension, arrhythmia, and apnea) and sedation profiles were assessed.Twenty-two original RCTs investigating a total of 1,798 patients, of whom 912 received propofol only and 886 received traditional sedative agents only, met the inclusion criteria. Propofol use was associated with shorter recovery (13 studies, 1,165 patients; WMD -19.75; 95% CI -27.65, 11.86) and discharge times (seven studies, 471 patients; WMD -29.48; 95% CI -44.13, -14.83), higher post-anesthesia recovery scores (four studies, 503 patients; WMD 2.03; 95% CI 1.59, 2.46), better sedation (nine studies, 592 patients; OR 4.78; 95% CI 2.56, 8.93), and greater patient cooperation (six studies, 709 patients; WMD 1.27; 95% CI 0.53, 2.02), as well as more local pain on injection (six studies, 547 patients; OR 10.19; 95% CI 3.93, 26.39). Effects of propofol on cardiopulmonary complications, procedure duration, amnesia, pain during endoscopy, and patient satisfaction were not found to be significantly different from those of traditional sedative agents.Propofol is safe and effective for gastrointestinal endoscopy procedures and is associated with shorter recovery and discharge periods, higher post-anesthesia recovery scores, better sedation, and greater patient cooperation than traditional sedation, without an increase in cardiopulmonary complications. Care should be taken when extrapolating our results to specific practice settings and high-risk patient subgroups. |
| first_indexed | 2024-12-10T22:47:55Z |
| format | Article |
| id | doaj.art-73260ce414fe476fa9044bd83b90c16d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T22:47:55Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-73260ce414fe476fa9044bd83b90c16d2022-12-22T01:30:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5331110.1371/journal.pone.0053311The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.Daorong WangChaowu ChenJie ChenYaxiang XuLu WangZhen ZhuDenghao DengJuan ChenAihua LongDong TangJun LiuTo assess the efficacy and safety of propofol sedation for gastrointestinal endoscopy, we conducted a meta-analysis of randomized controlled trials (RCTs) comparing propofol with traditional sedative agents.RCTs comparing the effects of propofol and traditional sedative agents during gastrointestinal endoscopy were found on MEDLINE, the Cochrane Central Register of Controlled Trials, and EMBASE. Cardiopulmonary complications (i.e., hypoxia, hypotension, arrhythmia, and apnea) and sedation profiles were assessed.Twenty-two original RCTs investigating a total of 1,798 patients, of whom 912 received propofol only and 886 received traditional sedative agents only, met the inclusion criteria. Propofol use was associated with shorter recovery (13 studies, 1,165 patients; WMD -19.75; 95% CI -27.65, 11.86) and discharge times (seven studies, 471 patients; WMD -29.48; 95% CI -44.13, -14.83), higher post-anesthesia recovery scores (four studies, 503 patients; WMD 2.03; 95% CI 1.59, 2.46), better sedation (nine studies, 592 patients; OR 4.78; 95% CI 2.56, 8.93), and greater patient cooperation (six studies, 709 patients; WMD 1.27; 95% CI 0.53, 2.02), as well as more local pain on injection (six studies, 547 patients; OR 10.19; 95% CI 3.93, 26.39). Effects of propofol on cardiopulmonary complications, procedure duration, amnesia, pain during endoscopy, and patient satisfaction were not found to be significantly different from those of traditional sedative agents.Propofol is safe and effective for gastrointestinal endoscopy procedures and is associated with shorter recovery and discharge periods, higher post-anesthesia recovery scores, better sedation, and greater patient cooperation than traditional sedation, without an increase in cardiopulmonary complications. Care should be taken when extrapolating our results to specific practice settings and high-risk patient subgroups.http://europepmc.org/articles/PMC3540096?pdf=render |
| spellingShingle | Daorong Wang Chaowu Chen Jie Chen Yaxiang Xu Lu Wang Zhen Zhu Denghao Deng Juan Chen Aihua Long Dong Tang Jun Liu The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis. PLoS ONE |
| title | The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis. |
| title_full | The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis. |
| title_fullStr | The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis. |
| title_full_unstemmed | The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis. |
| title_short | The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis. |
| title_sort | use of propofol as a sedative agent in gastrointestinal endoscopy a meta analysis |
| url | http://europepmc.org/articles/PMC3540096?pdf=render |
| work_keys_str_mv | AT daorongwang theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT chaowuchen theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT jiechen theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT yaxiangxu theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT luwang theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT zhenzhu theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT denghaodeng theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT juanchen theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT aihualong theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT dongtang theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT junliu theuseofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT daorongwang useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT chaowuchen useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT jiechen useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT yaxiangxu useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT luwang useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT zhenzhu useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT denghaodeng useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT juanchen useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT aihualong useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT dongtang useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis AT junliu useofpropofolasasedativeagentingastrointestinalendoscopyametaanalysis |