The Role of Macrophages in the Pathogenesis of Atherosclerosis
A wide variety of cell populations, including both immune and endothelial cells, participate in the pathogenesis of atherosclerosis. Among these groups, macrophages deserve special attention because different populations of them can have completely different effects on atherogenesis and inflammation...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/4/522 |
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| author | Alexander V. Blagov Alexander M. Markin Anastasia I. Bogatyreva Taisiya V. Tolstik Vasily N. Sukhorukov Alexander N. Orekhov |
| author_facet | Alexander V. Blagov Alexander M. Markin Anastasia I. Bogatyreva Taisiya V. Tolstik Vasily N. Sukhorukov Alexander N. Orekhov |
| author_sort | Alexander V. Blagov |
| collection | DOAJ |
| description | A wide variety of cell populations, including both immune and endothelial cells, participate in the pathogenesis of atherosclerosis. Among these groups, macrophages deserve special attention because different populations of them can have completely different effects on atherogenesis and inflammation in atherosclerosis. In the current review, the significance of different phenotypes of macrophages in the progression or regression of atherosclerosis will be considered, including their ability to become the foam cells and the consequences of this event, as well as their ability to create a pro-inflammatory or anti-inflammatory medium at the site of atherosclerotic lesions as a result of cytokine production. In addition, several therapeutic strategies directed to the modulation of macrophage activity, which can serve as useful ideas for future drug developments, will be considered. |
| first_indexed | 2024-03-11T09:00:56Z |
| format | Article |
| id | doaj.art-7326c81b5533491288753f862d55c724 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T09:00:56Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7326c81b5533491288753f862d55c7242023-11-16T19:43:29ZengMDPI AGCells2073-44092023-02-0112452210.3390/cells12040522The Role of Macrophages in the Pathogenesis of AtherosclerosisAlexander V. Blagov0Alexander M. Markin1Anastasia I. Bogatyreva2Taisiya V. Tolstik3Vasily N. Sukhorukov4Alexander N. Orekhov5Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, 125315 Moscow, RussiaPetrovsky National Research Centre of Surgery, 119991 Moscow, RussiaPetrovsky National Research Centre of Surgery, 119991 Moscow, RussiaPetrovsky National Research Centre of Surgery, 119991 Moscow, RussiaPetrovsky National Research Centre of Surgery, 119991 Moscow, RussiaInstitute for Atherosclerosis Research, 121609 Moscow, RussiaA wide variety of cell populations, including both immune and endothelial cells, participate in the pathogenesis of atherosclerosis. Among these groups, macrophages deserve special attention because different populations of them can have completely different effects on atherogenesis and inflammation in atherosclerosis. In the current review, the significance of different phenotypes of macrophages in the progression or regression of atherosclerosis will be considered, including their ability to become the foam cells and the consequences of this event, as well as their ability to create a pro-inflammatory or anti-inflammatory medium at the site of atherosclerotic lesions as a result of cytokine production. In addition, several therapeutic strategies directed to the modulation of macrophage activity, which can serve as useful ideas for future drug developments, will be considered.https://www.mdpi.com/2073-4409/12/4/522atherosclerosismacrophagespolarization |
| spellingShingle | Alexander V. Blagov Alexander M. Markin Anastasia I. Bogatyreva Taisiya V. Tolstik Vasily N. Sukhorukov Alexander N. Orekhov The Role of Macrophages in the Pathogenesis of Atherosclerosis Cells atherosclerosis macrophages polarization |
| title | The Role of Macrophages in the Pathogenesis of Atherosclerosis |
| title_full | The Role of Macrophages in the Pathogenesis of Atherosclerosis |
| title_fullStr | The Role of Macrophages in the Pathogenesis of Atherosclerosis |
| title_full_unstemmed | The Role of Macrophages in the Pathogenesis of Atherosclerosis |
| title_short | The Role of Macrophages in the Pathogenesis of Atherosclerosis |
| title_sort | role of macrophages in the pathogenesis of atherosclerosis |
| topic | atherosclerosis macrophages polarization |
| url | https://www.mdpi.com/2073-4409/12/4/522 |
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