Warfarin-induced deep vein thrombosis
Khalid A Binymin,1 Magda Nasher,2 Dipti Patel2 1Liverpool University, Medical School, England, UK; 2Southport and Ormskirk NHS Trust, Southport District General Hospital, Kew, UK Abstract: We are presenting a 72-year-old female who was admitted to hospital with deep vein thrombosis (DVT). She was k...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2014-09-01
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| Series: | International Medical Case Reports Journal |
| Online Access: | http://www.dovepress.com/warfarin-induced-deep-vein-thrombosis-peer-reviewed-article-IMCRJ |
| _version_ | 1819123051084644352 |
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| author | Binymin KA Nasher M Patel D |
| author_facet | Binymin KA Nasher M Patel D |
| author_sort | Binymin KA |
| collection | DOAJ |
| description | Khalid A Binymin,1 Magda Nasher,2 Dipti Patel2 1Liverpool University, Medical School, England, UK; 2Southport and Ormskirk NHS Trust, Southport District General Hospital, Kew, UK Abstract: We are presenting a 72-year-old female who was admitted to hospital with deep vein thrombosis (DVT). She was known to have atrial fibrillation and was initiated on warfarin for stroke prophylaxis 3 days earlier. She was given warfarin therapy without low molecular weight heparin cover as per “slow-start regimen” protocol. The warfarin dose was increased after 3 days to achieve rapid anticoagulation, resulting in DVT in the left leg. We propose that the higher unopposed warfarin dose utilized in this case resulted in DVT. Warfarin loading doses may paradoxically result in a hypercoagulable state and potential clot formation because of significant reductions in protein C and protein S levels. Keywords: warfarin, deep vein thrombosis, slow-start regimen, protein C, protein S, warfarin-induced skin necrosis, stroke prophylaxis |
| first_indexed | 2024-12-22T07:02:12Z |
| format | Article |
| id | doaj.art-73271d4e5f564cadb01b388ade6bf034 |
| institution | Directory Open Access Journal |
| issn | 1179-142X |
| language | English |
| last_indexed | 2024-12-22T07:02:12Z |
| publishDate | 2014-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj.art-73271d4e5f564cadb01b388ade6bf0342022-12-21T18:34:47ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2014-09-012014default12312518252Warfarin-induced deep vein thrombosisBinymin KANasher MPatel DKhalid A Binymin,1 Magda Nasher,2 Dipti Patel2 1Liverpool University, Medical School, England, UK; 2Southport and Ormskirk NHS Trust, Southport District General Hospital, Kew, UK Abstract: We are presenting a 72-year-old female who was admitted to hospital with deep vein thrombosis (DVT). She was known to have atrial fibrillation and was initiated on warfarin for stroke prophylaxis 3 days earlier. She was given warfarin therapy without low molecular weight heparin cover as per “slow-start regimen” protocol. The warfarin dose was increased after 3 days to achieve rapid anticoagulation, resulting in DVT in the left leg. We propose that the higher unopposed warfarin dose utilized in this case resulted in DVT. Warfarin loading doses may paradoxically result in a hypercoagulable state and potential clot formation because of significant reductions in protein C and protein S levels. Keywords: warfarin, deep vein thrombosis, slow-start regimen, protein C, protein S, warfarin-induced skin necrosis, stroke prophylaxishttp://www.dovepress.com/warfarin-induced-deep-vein-thrombosis-peer-reviewed-article-IMCRJ |
| spellingShingle | Binymin KA Nasher M Patel D Warfarin-induced deep vein thrombosis International Medical Case Reports Journal |
| title | Warfarin-induced deep vein thrombosis |
| title_full | Warfarin-induced deep vein thrombosis |
| title_fullStr | Warfarin-induced deep vein thrombosis |
| title_full_unstemmed | Warfarin-induced deep vein thrombosis |
| title_short | Warfarin-induced deep vein thrombosis |
| title_sort | warfarin induced deep vein thrombosis |
| url | http://www.dovepress.com/warfarin-induced-deep-vein-thrombosis-peer-reviewed-article-IMCRJ |
| work_keys_str_mv | AT binyminka warfarininduceddeepveinthrombosis AT nasherm warfarininduceddeepveinthrombosis AT pateld warfarininduceddeepveinthrombosis |