Identification of the New Metabolite of Nebivolol Using Liquid Chromatography Coupled with High-Resolution Mass Spectrometry and Chemometrics

Identification of the New Metabolite of Nebivolol Using Liquid Chromatography Coupled with High-Resolution Mass Spectrometry and Chemometrics

In this study, the phase I hepatic metabolism pathway of a cardiovascular drug nebivolol was proposed on the basis of a human liver microsomes assay with the use of LC-HR-MS coupled with the chemometric method. Six biotransformation products were found with the assistance of chemometric analysis. Fi...

Full description

Bibliographic Details
Main Authors: Jakub Trawiński, Michał Wroński, Maciej Gawlik, Robert Skibiński
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
chromatography
mass spectrometry
drug metabolism
biotransformation
HLM
toxicity
Online Access:https://www.mdpi.com/1420-3049/27/3/763

Similar Items

Similar Items