What the SIF Is Happening—The Role of Intracellular Salmonella-Induced Filaments
A common strategy among intracellular bacterial pathogens is to enter into a vacuolar environment upon host cell invasion. One such pathogen, Salmonella enterica, resides within the Salmonella-containing vacuole (SCV) inside epithelial cells and macrophages. Salmonella hijacks the host endosomal sys...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcimb.2017.00335/full |
| _version_ | 1818114235118387200 |
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| author | Katelyn Knuff Katelyn Knuff B. Brett Finlay B. Brett Finlay B. Brett Finlay |
| author_facet | Katelyn Knuff Katelyn Knuff B. Brett Finlay B. Brett Finlay B. Brett Finlay |
| author_sort | Katelyn Knuff |
| collection | DOAJ |
| description | A common strategy among intracellular bacterial pathogens is to enter into a vacuolar environment upon host cell invasion. One such pathogen, Salmonella enterica, resides within the Salmonella-containing vacuole (SCV) inside epithelial cells and macrophages. Salmonella hijacks the host endosomal system to establish this unique intracellular replicative niche, forming a highly complex and dynamic network of Salmonella-induced filaments (SIFs). SIFs radiate outwards from the SCV upon onset of bacterial replication. SIF biogenesis is dependent on the activity of bacterial effector proteins secreted by the Salmonella-pathogenicity island-2 (SPI-2) encoded type III secretion system. While the presence of SIFs has been known for almost 25 years, their precise role during infection remains elusive. This review summarizes our current knowledge of SCV maturation and SIF biogenesis, and recent advances in our understanding of the role of SIFs inside cells. |
| first_indexed | 2024-12-11T03:47:30Z |
| format | Article |
| id | doaj.art-732c2f2b82f34c51a402e1e797d7b2f6 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-11T03:47:30Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-732c2f2b82f34c51a402e1e797d7b2f62022-12-22T01:21:59ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882017-07-01710.3389/fcimb.2017.00335284349What the SIF Is Happening—The Role of Intracellular Salmonella-Induced FilamentsKatelyn Knuff0Katelyn Knuff1B. Brett Finlay2B. Brett Finlay3B. Brett Finlay4Michael Smith Laboratories, University of British ColumbiaVancouver, BC, CanadaDepartment of Microbiology and Immunology, University of British ColumbiaVancouver, BC, CanadaMichael Smith Laboratories, University of British ColumbiaVancouver, BC, CanadaDepartment of Microbiology and Immunology, University of British ColumbiaVancouver, BC, CanadaDepartment of Biochemistry and Molecular Biology, University of British ColumbiaVancouver, BC, CanadaA common strategy among intracellular bacterial pathogens is to enter into a vacuolar environment upon host cell invasion. One such pathogen, Salmonella enterica, resides within the Salmonella-containing vacuole (SCV) inside epithelial cells and macrophages. Salmonella hijacks the host endosomal system to establish this unique intracellular replicative niche, forming a highly complex and dynamic network of Salmonella-induced filaments (SIFs). SIFs radiate outwards from the SCV upon onset of bacterial replication. SIF biogenesis is dependent on the activity of bacterial effector proteins secreted by the Salmonella-pathogenicity island-2 (SPI-2) encoded type III secretion system. While the presence of SIFs has been known for almost 25 years, their precise role during infection remains elusive. This review summarizes our current knowledge of SCV maturation and SIF biogenesis, and recent advances in our understanding of the role of SIFs inside cells.http://journal.frontiersin.org/article/10.3389/fcimb.2017.00335/fullSalmonella typhimuriumSalmonella-induced filamentsSalmonella-containing vacuolemultiple contact sitesendosomal system |
| spellingShingle | Katelyn Knuff Katelyn Knuff B. Brett Finlay B. Brett Finlay B. Brett Finlay What the SIF Is Happening—The Role of Intracellular Salmonella-Induced Filaments Frontiers in Cellular and Infection Microbiology Salmonella typhimurium Salmonella-induced filaments Salmonella-containing vacuole multiple contact sites endosomal system |
| title | What the SIF Is Happening—The Role of Intracellular Salmonella-Induced Filaments |
| title_full | What the SIF Is Happening—The Role of Intracellular Salmonella-Induced Filaments |
| title_fullStr | What the SIF Is Happening—The Role of Intracellular Salmonella-Induced Filaments |
| title_full_unstemmed | What the SIF Is Happening—The Role of Intracellular Salmonella-Induced Filaments |
| title_short | What the SIF Is Happening—The Role of Intracellular Salmonella-Induced Filaments |
| title_sort | what the sif is happening the role of intracellular salmonella induced filaments |
| topic | Salmonella typhimurium Salmonella-induced filaments Salmonella-containing vacuole multiple contact sites endosomal system |
| url | http://journal.frontiersin.org/article/10.3389/fcimb.2017.00335/full |
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