YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis
Abstract Small cell lung cancer (SCLC) is highly lethal due to its prevalent metastasis. Most SCLCs have inactivating mutations in TP53 and RB1. We find that loss of YAP expression is key for SCLC cells to acquire rapid ameboid migration and high metastatic potential. YAP functions through its targe...
Main Authors: | Zhengming Wu, Junhui Su, Fu-long Li, Tao Chen, Jaimie Mayner, Adam Engler, Shenghong Ma, Qingquan Li, Kun-Liang Guan |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-41585-z |
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