RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
As the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest even...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/11/2172 |
| _version_ | 1797508210947522560 |
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| author | Samantha Lisy Katherine Rothamel Manuel Ascano |
| author_facet | Samantha Lisy Katherine Rothamel Manuel Ascano |
| author_sort | Samantha Lisy |
| collection | DOAJ |
| description | As the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest events between viral RNA and the RBPs that act upon them. These discoveries have sparked a re-evaluation of current paradigms surrounding RBPs and post-transcriptional gene regulation. Here, we highlight questions that have bloomed from the implementation of these novel approaches. Canonical RBPs can impact the fates of both cellular and viral RNA during infection, sometimes in conflicting ways. Noncanonical RBPs, some of which were first characterized via interactions with viral RNA, may encompass physiological roles beyond viral pathogenesis. We discuss how these RBPs might discriminate between an RNA of either cellular or viral origin and thus exert either pro- or antiviral effects—which is a particular challenge as viruses contain mechanisms to mimic molecular features of cellular RNA. |
| first_indexed | 2024-03-10T04:59:13Z |
| format | Article |
| id | doaj.art-732d999924104d12a5a3b5fd6b1b3ac2 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T04:59:13Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-732d999924104d12a5a3b5fd6b1b3ac22023-11-23T01:56:05ZengMDPI AGViruses1999-49152021-10-011311217210.3390/v13112172RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?Samantha Lisy0Katherine Rothamel1Manuel Ascano2Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USADepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USADepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USAAs the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest events between viral RNA and the RBPs that act upon them. These discoveries have sparked a re-evaluation of current paradigms surrounding RBPs and post-transcriptional gene regulation. Here, we highlight questions that have bloomed from the implementation of these novel approaches. Canonical RBPs can impact the fates of both cellular and viral RNA during infection, sometimes in conflicting ways. Noncanonical RBPs, some of which were first characterized via interactions with viral RNA, may encompass physiological roles beyond viral pathogenesis. We discuss how these RBPs might discriminate between an RNA of either cellular or viral origin and thus exert either pro- or antiviral effects—which is a particular challenge as viruses contain mechanisms to mimic molecular features of cellular RNA.https://www.mdpi.com/1999-4915/13/11/2172RNA binding proteinsinnate immunityviral infectionhost vs. pathogenpost-transcriptional gene regulationRNA sensing |
| spellingShingle | Samantha Lisy Katherine Rothamel Manuel Ascano RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? Viruses RNA binding proteins innate immunity viral infection host vs. pathogen post-transcriptional gene regulation RNA sensing |
| title | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
| title_full | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
| title_fullStr | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
| title_full_unstemmed | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
| title_short | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
| title_sort | rna binding proteins as pioneer determinants of infection protective proviral or both |
| topic | RNA binding proteins innate immunity viral infection host vs. pathogen post-transcriptional gene regulation RNA sensing |
| url | https://www.mdpi.com/1999-4915/13/11/2172 |
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