Safety of Breast Cancer Mastoscopic Surgery from the Perspective of Immunity and Adipokines
Background: This study was performed to explore the safety of breast cancer (BC) mastoscopic surgery from the perspective of immunity and adipokines. Method: A single-center, prospective, randomized controlled trial was carried out among 42 patients who had undergone surgery from December 2018 to Ju...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-02-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2021.1919945 |
| _version_ | 1797684475436466176 |
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| author | Wenzhi Lv Boni Ding Liyuan Qian Wei Wu Yanguang Wen |
| author_facet | Wenzhi Lv Boni Ding Liyuan Qian Wei Wu Yanguang Wen |
| author_sort | Wenzhi Lv |
| collection | DOAJ |
| description | Background: This study was performed to explore the safety of breast cancer (BC) mastoscopic surgery from the perspective of immunity and adipokines. Method: A single-center, prospective, randomized controlled trial was carried out among 42 patients who had undergone surgery from December 2018 to July 2019. All patients were randomly divided into an open surgery group (n = 21) and a mastoscopic surgery group (n = 21). Flow cytometry was used to detect natural killer (NK), CD4+ T cells, CD8+ T cells, and regulatory T (Treg) cells in each group 1 d before surgery, 1 h after operation, and 1, 5, and 7 d after operation. The levels of serum leptin and adiponectin were detected by enzyme-linked immunosorbent assay before and after operation. Results: There were no significant differences in the percentages of NK (p = 0.984), CD4+ T (p = 0.591), Treg (p = 0.676), and CD8 + T (p = 0.341) lymphocytes between the two groups during the perioperative period. There were no significant differences in the levels of serum leptin and adiponectin before and after operation between the two groups (all p > 0.05). There were no significant differences between patients undergoing open surgery and mastoscopic surgery from the perspective of immunity and adipokines. Conclusion: Mastoscopic surgery is a suitable surgical choice for patients with BC. |
| first_indexed | 2024-03-12T00:30:13Z |
| format | Article |
| id | doaj.art-732da6d29f04462da1746746dddf2f76 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:30:13Z |
| publishDate | 2022-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-732da6d29f04462da1746746dddf2f762023-09-15T10:21:28ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532022-02-0135363263810.1080/08941939.2021.19199451919945Safety of Breast Cancer Mastoscopic Surgery from the Perspective of Immunity and AdipokinesWenzhi Lv0Boni Ding1Liyuan Qian2Wei Wu3Yanguang Wen4Department of Breast and Thyroid Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Breast and Thyroid Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Breast and Thyroid Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Breast and Thyroid Surgery, The Third Xiangya Hospital of Central South UniversityDepartment of Breast and Thyroid Surgery, The Third Xiangya Hospital of Central South UniversityBackground: This study was performed to explore the safety of breast cancer (BC) mastoscopic surgery from the perspective of immunity and adipokines. Method: A single-center, prospective, randomized controlled trial was carried out among 42 patients who had undergone surgery from December 2018 to July 2019. All patients were randomly divided into an open surgery group (n = 21) and a mastoscopic surgery group (n = 21). Flow cytometry was used to detect natural killer (NK), CD4+ T cells, CD8+ T cells, and regulatory T (Treg) cells in each group 1 d before surgery, 1 h after operation, and 1, 5, and 7 d after operation. The levels of serum leptin and adiponectin were detected by enzyme-linked immunosorbent assay before and after operation. Results: There were no significant differences in the percentages of NK (p = 0.984), CD4+ T (p = 0.591), Treg (p = 0.676), and CD8 + T (p = 0.341) lymphocytes between the two groups during the perioperative period. There were no significant differences in the levels of serum leptin and adiponectin before and after operation between the two groups (all p > 0.05). There were no significant differences between patients undergoing open surgery and mastoscopic surgery from the perspective of immunity and adipokines. Conclusion: Mastoscopic surgery is a suitable surgical choice for patients with BC.http://dx.doi.org/10.1080/08941939.2021.1919945adipokinesbreast cancerimmune systemmastoscopic surgery |
| spellingShingle | Wenzhi Lv Boni Ding Liyuan Qian Wei Wu Yanguang Wen Safety of Breast Cancer Mastoscopic Surgery from the Perspective of Immunity and Adipokines Journal of Investigative Surgery adipokines breast cancer immune system mastoscopic surgery |
| title | Safety of Breast Cancer Mastoscopic Surgery from the Perspective of Immunity and Adipokines |
| title_full | Safety of Breast Cancer Mastoscopic Surgery from the Perspective of Immunity and Adipokines |
| title_fullStr | Safety of Breast Cancer Mastoscopic Surgery from the Perspective of Immunity and Adipokines |
| title_full_unstemmed | Safety of Breast Cancer Mastoscopic Surgery from the Perspective of Immunity and Adipokines |
| title_short | Safety of Breast Cancer Mastoscopic Surgery from the Perspective of Immunity and Adipokines |
| title_sort | safety of breast cancer mastoscopic surgery from the perspective of immunity and adipokines |
| topic | adipokines breast cancer immune system mastoscopic surgery |
| url | http://dx.doi.org/10.1080/08941939.2021.1919945 |
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