Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2
In this paper, the influence of external terahertz electromagnetic fields with different frequencies of 4 THz, 10 THz, 15 THz, and 20 THz on the permeability of the Kv1.2 voltage-gated potassium ion channel on the nerve cell membrane was studied using the combined model of the “Constant Electric Fie...
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10271 |
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| author | Wen Ding Xiaofei Zhao Hongguang Wang Yize Wang Yanjiang Liu Lirong Gong Shu Lin Chunliang Liu Yongdong Li |
| author_facet | Wen Ding Xiaofei Zhao Hongguang Wang Yize Wang Yanjiang Liu Lirong Gong Shu Lin Chunliang Liu Yongdong Li |
| author_sort | Wen Ding |
| collection | DOAJ |
| description | In this paper, the influence of external terahertz electromagnetic fields with different frequencies of 4 THz, 10 THz, 15 THz, and 20 THz on the permeability of the Kv1.2 voltage-gated potassium ion channel on the nerve cell membrane was studied using the combined model of the “Constant Electric Field-Ion Imbalance” method by molecular dynamics. We found that although the applied terahertz electric field does not produce strong resonance with the –C=O groups of the conservative sequence T-V-G-Y-G amino acid residue of the selective filter (SF) of the channel, it would affect the stability of the electrostatic bond between potassium ions and the carbonyl group of T-V-G-Y-G of SF, and it would affect the stability of the hydrogen bond between water molecules and oxygen atoms of the hydroxyl group of the 374THR side chain at the SF entrance, changing the potential and occupied states of ions in the SF and the occurrence probability of the permeation mode of ions and resulting in the change in the permeability of the channel. Compared with no external electric field, when the external electric field with 15 THz frequency is applied, the lifetime of the hydrogen bond is reduced by 29%, the probability of the “soft knock on” mode is decreased by 46.9%, and the ion flux of the channel is activated by 67.7%. Our research results support the view that compared to “direct knock-on”, “soft knock-on” is a slower permeation mode. |
| first_indexed | 2024-03-11T02:20:25Z |
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| id | doaj.art-73301faeb9144b249174567b12bee488 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:20:25Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-73301faeb9144b249174567b12bee4882023-11-18T10:51:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121027110.3390/ijms241210271Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2Wen Ding0Xiaofei Zhao1Hongguang Wang2Yize Wang3Yanjiang Liu4Lirong Gong5Shu Lin6Chunliang Liu7Yongdong Li8Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, ChinaKey Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, ChinaKey Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, ChinaKey Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, ChinaKey Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, ChinaKey Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, ChinaKey Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, ChinaKey Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, ChinaKey Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, ChinaIn this paper, the influence of external terahertz electromagnetic fields with different frequencies of 4 THz, 10 THz, 15 THz, and 20 THz on the permeability of the Kv1.2 voltage-gated potassium ion channel on the nerve cell membrane was studied using the combined model of the “Constant Electric Field-Ion Imbalance” method by molecular dynamics. We found that although the applied terahertz electric field does not produce strong resonance with the –C=O groups of the conservative sequence T-V-G-Y-G amino acid residue of the selective filter (SF) of the channel, it would affect the stability of the electrostatic bond between potassium ions and the carbonyl group of T-V-G-Y-G of SF, and it would affect the stability of the hydrogen bond between water molecules and oxygen atoms of the hydroxyl group of the 374THR side chain at the SF entrance, changing the potential and occupied states of ions in the SF and the occurrence probability of the permeation mode of ions and resulting in the change in the permeability of the channel. Compared with no external electric field, when the external electric field with 15 THz frequency is applied, the lifetime of the hydrogen bond is reduced by 29%, the probability of the “soft knock on” mode is decreased by 46.9%, and the ion flux of the channel is activated by 67.7%. Our research results support the view that compared to “direct knock-on”, “soft knock-on” is a slower permeation mode.https://www.mdpi.com/1422-0067/24/12/10271Kv1.2 ion channelion permeation mechanismterahertz electromagnetic fieldhydrogen bond lifetime |
| spellingShingle | Wen Ding Xiaofei Zhao Hongguang Wang Yize Wang Yanjiang Liu Lirong Gong Shu Lin Chunliang Liu Yongdong Li Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2 International Journal of Molecular Sciences Kv1.2 ion channel ion permeation mechanism terahertz electromagnetic field hydrogen bond lifetime |
| title | Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2 |
| title_full | Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2 |
| title_fullStr | Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2 |
| title_full_unstemmed | Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2 |
| title_short | Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2 |
| title_sort | effect of terahertz electromagnetic field on the permeability of potassium channel kv1 2 |
| topic | Kv1.2 ion channel ion permeation mechanism terahertz electromagnetic field hydrogen bond lifetime |
| url | https://www.mdpi.com/1422-0067/24/12/10271 |
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