New insight into the role of the ADAM protease family in breast carcinoma progression
Protease and adhesion molecules play a very emphasized role in the occurrence or progression of metastasis in many types of cancers. In this context, a molecule that contains both protease and adhesion functions play a crucial role in metastasis. ADAMs (a disintegrin and metalloprotease) are molecul...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024008363 |
| _version_ | 1827348432970317824 |
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| author | Sepideh Aliniaye Navasatli Saeed Niazi Vahdati Tahura Fayeghi Arjmand Marjan Mohammadi far Hossein Behboudi |
| author_facet | Sepideh Aliniaye Navasatli Saeed Niazi Vahdati Tahura Fayeghi Arjmand Marjan Mohammadi far Hossein Behboudi |
| author_sort | Sepideh Aliniaye Navasatli |
| collection | DOAJ |
| description | Protease and adhesion molecules play a very emphasized role in the occurrence or progression of metastasis in many types of cancers. In this context, a molecule that contains both protease and adhesion functions play a crucial role in metastasis. ADAMs (a disintegrin and metalloprotease) are molecules with this special characteristic. Recently, a lot of attention has been attracted to various ADAM molecules and researchers have tried to elucidate the role of ADAMs in breast cancer occurrence and progression. Disrupting ADAMs protease and adhesion capabilities can lead to the discovery of worthy therapeutic targets in breast cancer treatment. In this review, we intend to discuss the mechanism of action of various ADAM molecules, their relation to pathogenic processes of breast cancer, and their potential as possible targets for breast cancer treatment. |
| first_indexed | 2024-03-08T00:12:10Z |
| format | Article |
| id | doaj.art-7330d4ee4ef14b059d5290a50613db81 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T00:12:10Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7330d4ee4ef14b059d5290a50613db812024-02-17T06:38:42ZengElsevierHeliyon2405-84402024-02-01103e24805New insight into the role of the ADAM protease family in breast carcinoma progressionSepideh Aliniaye Navasatli0Saeed Niazi Vahdati1Tahura Fayeghi Arjmand2Marjan Mohammadi far3Hossein Behboudi4Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, IranInstitute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, IranDepartment of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranInstitute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, IranDepartment of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran; Corresponding author.Protease and adhesion molecules play a very emphasized role in the occurrence or progression of metastasis in many types of cancers. In this context, a molecule that contains both protease and adhesion functions play a crucial role in metastasis. ADAMs (a disintegrin and metalloprotease) are molecules with this special characteristic. Recently, a lot of attention has been attracted to various ADAM molecules and researchers have tried to elucidate the role of ADAMs in breast cancer occurrence and progression. Disrupting ADAMs protease and adhesion capabilities can lead to the discovery of worthy therapeutic targets in breast cancer treatment. In this review, we intend to discuss the mechanism of action of various ADAM molecules, their relation to pathogenic processes of breast cancer, and their potential as possible targets for breast cancer treatment.http://www.sciencedirect.com/science/article/pii/S2405844024008363A disintegrin and metalloproteaseBreast cancerMetastasisTreatment |
| spellingShingle | Sepideh Aliniaye Navasatli Saeed Niazi Vahdati Tahura Fayeghi Arjmand Marjan Mohammadi far Hossein Behboudi New insight into the role of the ADAM protease family in breast carcinoma progression Heliyon A disintegrin and metalloprotease Breast cancer Metastasis Treatment |
| title | New insight into the role of the ADAM protease family in breast carcinoma progression |
| title_full | New insight into the role of the ADAM protease family in breast carcinoma progression |
| title_fullStr | New insight into the role of the ADAM protease family in breast carcinoma progression |
| title_full_unstemmed | New insight into the role of the ADAM protease family in breast carcinoma progression |
| title_short | New insight into the role of the ADAM protease family in breast carcinoma progression |
| title_sort | new insight into the role of the adam protease family in breast carcinoma progression |
| topic | A disintegrin and metalloprotease Breast cancer Metastasis Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024008363 |
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