The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices
Heart failure, a common clinical syndrome caused by functional and structural abnormalities of the heart, affects 64 million people worldwide. Long-term mechanical circulatory support can offer lifesaving treatment for end-stage systolic heart failure patients. However, this treatment is not without...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Hearts |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-3846/5/1/8 |
| _version_ | 1827306107749531648 |
|---|---|
| author | Christian R. Sargent Sabrina Ali Venkateswarlu Kanamarlapudi |
| author_facet | Christian R. Sargent Sabrina Ali Venkateswarlu Kanamarlapudi |
| author_sort | Christian R. Sargent |
| collection | DOAJ |
| description | Heart failure, a common clinical syndrome caused by functional and structural abnormalities of the heart, affects 64 million people worldwide. Long-term mechanical circulatory support can offer lifesaving treatment for end-stage systolic heart failure patients. However, this treatment is not without complications. This review covers the major complications associated with implantable mechanical circulatory support devices, including strokes, pump thrombosis and gastrointestinal bleeding. These complications were assessed in patients implanted with the following devices: Novacor, HeartMate XVE, CardioWest, Jarvik 2000, HeartMate II, EVAHEART, Incor, VentrAssist, HVAD and HeartMate 3. Complication rates vary among devices and remain despite the introduction of more advanced technology, highlighting the importance of device design and flow patterns. Beyond clinical implications, the cost of complications was explored, highlighting the difference in costs and the need for equitable healthcare, especially with the expected rise in the use of mechanical circulatory support. Future directions include continued improvement through advancements in design and technology to reduce blood stagnation and mitigate high levels of shear stress. Ultimately, these alterations can reduce complications and enhance cost-effectiveness, enhancing both the survival and quality of life for patients receiving mechanical circulatory support. |
| first_indexed | 2024-04-24T18:13:32Z |
| format | Article |
| id | doaj.art-7331b516327e46a7ae62ccb5cf139c0a |
| institution | Directory Open Access Journal |
| issn | 2673-3846 |
| language | English |
| last_indexed | 2024-04-24T18:13:32Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hearts |
| spelling | doaj.art-7331b516327e46a7ae62ccb5cf139c0a2024-03-27T13:43:54ZengMDPI AGHearts2673-38462024-02-015110512110.3390/hearts5010008The Evolution and Complications of Long-Term Mechanical Circulatory Support DevicesChristian R. Sargent0Sabrina Ali1Venkateswarlu Kanamarlapudi2Calon Cardio Technology Ltd., ILS II, Swansea University, Swansea SA2 8PP, UKCalon Cardio Technology Ltd., ILS II, Swansea University, Swansea SA2 8PP, UKSingleton Park Campus, Swansea University Medical School, ILS I, Swansea SA2 8PP, UKHeart failure, a common clinical syndrome caused by functional and structural abnormalities of the heart, affects 64 million people worldwide. Long-term mechanical circulatory support can offer lifesaving treatment for end-stage systolic heart failure patients. However, this treatment is not without complications. This review covers the major complications associated with implantable mechanical circulatory support devices, including strokes, pump thrombosis and gastrointestinal bleeding. These complications were assessed in patients implanted with the following devices: Novacor, HeartMate XVE, CardioWest, Jarvik 2000, HeartMate II, EVAHEART, Incor, VentrAssist, HVAD and HeartMate 3. Complication rates vary among devices and remain despite the introduction of more advanced technology, highlighting the importance of device design and flow patterns. Beyond clinical implications, the cost of complications was explored, highlighting the difference in costs and the need for equitable healthcare, especially with the expected rise in the use of mechanical circulatory support. Future directions include continued improvement through advancements in design and technology to reduce blood stagnation and mitigate high levels of shear stress. Ultimately, these alterations can reduce complications and enhance cost-effectiveness, enhancing both the survival and quality of life for patients receiving mechanical circulatory support.https://www.mdpi.com/2673-3846/5/1/8heart failuremechanical circulatory supportcomplicationsventricular assist device |
| spellingShingle | Christian R. Sargent Sabrina Ali Venkateswarlu Kanamarlapudi The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices Hearts heart failure mechanical circulatory support complications ventricular assist device |
| title | The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
| title_full | The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
| title_fullStr | The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
| title_full_unstemmed | The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
| title_short | The Evolution and Complications of Long-Term Mechanical Circulatory Support Devices |
| title_sort | evolution and complications of long term mechanical circulatory support devices |
| topic | heart failure mechanical circulatory support complications ventricular assist device |
| url | https://www.mdpi.com/2673-3846/5/1/8 |
| work_keys_str_mv | AT christianrsargent theevolutionandcomplicationsoflongtermmechanicalcirculatorysupportdevices AT sabrinaali theevolutionandcomplicationsoflongtermmechanicalcirculatorysupportdevices AT venkateswarlukanamarlapudi theevolutionandcomplicationsoflongtermmechanicalcirculatorysupportdevices AT christianrsargent evolutionandcomplicationsoflongtermmechanicalcirculatorysupportdevices AT sabrinaali evolutionandcomplicationsoflongtermmechanicalcirculatorysupportdevices AT venkateswarlukanamarlapudi evolutionandcomplicationsoflongtermmechanicalcirculatorysupportdevices |