Establishment of Endoscopic Surgical Innovative System of Recurrent Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is a common malignant tumor in China. Radiotherapy is the first-line treatment. After appropriate radiotherapy, about 5%-15% patients experience recurrence. In view of the poor efficacy and high incidence of severe late toxicities associated with re-irradiation, salvag...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2022-09-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0468 |
| _version_ | 1817986232913756160 |
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| author | ZHANG Huankang DU Kun LIU Quan XUE Kai GU Ye ZHAO Weidong LI Wanpeng SONG Xiaole ZHAO Keqing LI Han HU Li LIU Qiang YU Huapeng GU Yurong SUN Xicai YU Hongmeng |
| author_facet | ZHANG Huankang DU Kun LIU Quan XUE Kai GU Ye ZHAO Weidong LI Wanpeng SONG Xiaole ZHAO Keqing LI Han HU Li LIU Qiang YU Huapeng GU Yurong SUN Xicai YU Hongmeng |
| author_sort | ZHANG Huankang |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma (NPC) is a common malignant tumor in China. Radiotherapy is the first-line treatment. After appropriate radiotherapy, about 5%-15% patients experience recurrence. In view of the poor efficacy and high incidence of severe late toxicities associated with re-irradiation, salvage surgery by the transnasal endoscopic approach is recommended for recurrent NPC (rNPC). Compared with re-irradiation, endoscopic surgery can better prolong survival, improve the quality of life, and reduce complications and medical expenses of patients with rNPC. However, the complexity of the nasopharyngeal skull base enhances the difficulty and risk of surgery. Expanding the boundary of surgical resection remains a clinical challenge for otolaryngologists. In this regard, to help more advanced patients with rNPC, the surgical innovative system of NPC needs to be established by multi-disciplinary cooperation, involving skull base anatomy-based investigation, appropriate administration of the internal carotid artery (ICA), repair of skull base defect, and establishment of various types of endoscopic endonasal nasopharyngectomy. |
| first_indexed | 2024-04-14T00:07:47Z |
| format | Article |
| id | doaj.art-73321fd29bcd406c97a00d89e5c01393 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-04-14T00:07:47Z |
| publishDate | 2022-09-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-73321fd29bcd406c97a00d89e5c013932022-12-22T02:23:29ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782022-09-0149986386910.3971/j.issn.1000-8578.2022.22.04688578.2022.22.0468Establishment of Endoscopic Surgical Innovative System of Recurrent Nasopharyngeal CarcinomaZHANG Huankang0DU Kun1LIU Quan2XUE Kai3GU Ye4ZHAO Weidong5LI Wanpeng6SONG Xiaole7ZHAO Keqing8LI Han9HU Li10LIU Qiang11YU Huapeng12GU Yurong13SUN Xicai14YU Hongmeng15Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Neurosurgery, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Neurosurgery, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Radiology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaNasopharyngeal carcinoma (NPC) is a common malignant tumor in China. Radiotherapy is the first-line treatment. After appropriate radiotherapy, about 5%-15% patients experience recurrence. In view of the poor efficacy and high incidence of severe late toxicities associated with re-irradiation, salvage surgery by the transnasal endoscopic approach is recommended for recurrent NPC (rNPC). Compared with re-irradiation, endoscopic surgery can better prolong survival, improve the quality of life, and reduce complications and medical expenses of patients with rNPC. However, the complexity of the nasopharyngeal skull base enhances the difficulty and risk of surgery. Expanding the boundary of surgical resection remains a clinical challenge for otolaryngologists. In this regard, to help more advanced patients with rNPC, the surgical innovative system of NPC needs to be established by multi-disciplinary cooperation, involving skull base anatomy-based investigation, appropriate administration of the internal carotid artery (ICA), repair of skull base defect, and establishment of various types of endoscopic endonasal nasopharyngectomy.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0468recurrent nasopharyngeal carcinomaendoscopic surgeryinternal carotid arterytemporalis muscle flapskull base repair |
| spellingShingle | ZHANG Huankang DU Kun LIU Quan XUE Kai GU Ye ZHAO Weidong LI Wanpeng SONG Xiaole ZHAO Keqing LI Han HU Li LIU Qiang YU Huapeng GU Yurong SUN Xicai YU Hongmeng Establishment of Endoscopic Surgical Innovative System of Recurrent Nasopharyngeal Carcinoma Zhongliu Fangzhi Yanjiu recurrent nasopharyngeal carcinoma endoscopic surgery internal carotid artery temporalis muscle flap skull base repair |
| title | Establishment of Endoscopic Surgical Innovative System of Recurrent Nasopharyngeal Carcinoma |
| title_full | Establishment of Endoscopic Surgical Innovative System of Recurrent Nasopharyngeal Carcinoma |
| title_fullStr | Establishment of Endoscopic Surgical Innovative System of Recurrent Nasopharyngeal Carcinoma |
| title_full_unstemmed | Establishment of Endoscopic Surgical Innovative System of Recurrent Nasopharyngeal Carcinoma |
| title_short | Establishment of Endoscopic Surgical Innovative System of Recurrent Nasopharyngeal Carcinoma |
| title_sort | establishment of endoscopic surgical innovative system of recurrent nasopharyngeal carcinoma |
| topic | recurrent nasopharyngeal carcinoma endoscopic surgery internal carotid artery temporalis muscle flap skull base repair |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0468 |
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