Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein

Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein

Abstract Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer, the third leading cause of cancer-associated death worldwide. With the increasing prevalence of metabolic conditions, non-alcoholic fatty liver disease (NAFLD) is emerging as the fastest-growing HCC risk factor, and it...

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Bibliographic Details
Main Authors: Xin Tracy Liu, Long Hoa Chung, Da Liu, Jinbiao Chen, Yu Huang, Jonathan D. Teo, Xingxing Daisy Han, Yinan Zhao, Fiona H. X. Guan, Collin Tran, Jun Yup Lee, Timothy A. Couttas, Ken Liu, Geoffery W. McCaughan, Mark D. Gorrell, Anthony S. Don, Shubiao Zhang, Yanfei Qi
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-022-00444-0

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