UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients
Abstract Background The uncoupling proteins (UCPs) are critical genes associated with tumorigenesis and chemoresistance. However, little is known about the molecular mechanism of the UCPs in ovarian cancer (OV). Material and methods UCPs expression analysis was conducted using Gene Expression Profil...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-022-00951-z |
| _version_ | 1797973076860731392 |
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| author | Jinfa Huang Guilian Wang Kedan Liao Ning Xie Kaixian Deng |
| author_facet | Jinfa Huang Guilian Wang Kedan Liao Ning Xie Kaixian Deng |
| author_sort | Jinfa Huang |
| collection | DOAJ |
| description | Abstract Background The uncoupling proteins (UCPs) are critical genes associated with tumorigenesis and chemoresistance. However, little is known about the molecular mechanism of the UCPs in ovarian cancer (OV). Material and methods UCPs expression analysis was conducted using Gene Expression Profiling Interactive Analysis (GEPIA), and its potential in clinical prognosis was analyzed using Kaplan- Meier analyses. The influence of UCPs on immune infiltration was analyzed by TIMER. In addition, the correlation between UCPs expression and molecular mechanisms was investigated by TIMER and Cancer Single-cell State Atlas (CancerSEA). Results UCP1, UCP2, UCP3 and UCP5 expression levels correlated with a favorable prognosis and tumor progression. Moreover, UCP1 expression correlated to several immune cell markers and regulated tumorigenesis, such as tumor invasion, EMT, metastasis and DNA repair. In addition, UCP1 potentially involved in genes expression of SNAI2, MMP2, BRCA1 and PARP1. Conclusions These results implied a critical role of UCP1 in the prognosis and immune infiltration of ovarian cancer. In addition, UCP1 expression participated in regulating multiple oncogenes and tumorigenesis. |
| first_indexed | 2024-04-11T03:58:29Z |
| format | Article |
| id | doaj.art-73383e754c4a491aaec82e3066a45ac5 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:58:29Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-73383e754c4a491aaec82e3066a45ac52023-01-02T00:01:16ZengBMCJournal of Ovarian Research1757-22152022-01-011511810.1186/s13048-022-00951-zUCP1 modulates immune infiltration level and survival outcome in ovarian cancer patientsJinfa Huang0Guilian Wang1Kedan Liao2Ning Xie3Kaixian Deng4Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Abstract Background The uncoupling proteins (UCPs) are critical genes associated with tumorigenesis and chemoresistance. However, little is known about the molecular mechanism of the UCPs in ovarian cancer (OV). Material and methods UCPs expression analysis was conducted using Gene Expression Profiling Interactive Analysis (GEPIA), and its potential in clinical prognosis was analyzed using Kaplan- Meier analyses. The influence of UCPs on immune infiltration was analyzed by TIMER. In addition, the correlation between UCPs expression and molecular mechanisms was investigated by TIMER and Cancer Single-cell State Atlas (CancerSEA). Results UCP1, UCP2, UCP3 and UCP5 expression levels correlated with a favorable prognosis and tumor progression. Moreover, UCP1 expression correlated to several immune cell markers and regulated tumorigenesis, such as tumor invasion, EMT, metastasis and DNA repair. In addition, UCP1 potentially involved in genes expression of SNAI2, MMP2, BRCA1 and PARP1. Conclusions These results implied a critical role of UCP1 in the prognosis and immune infiltration of ovarian cancer. In addition, UCP1 expression participated in regulating multiple oncogenes and tumorigenesis.https://doi.org/10.1186/s13048-022-00951-zOvarian cancerUCP1Immune infiltration levelTumorigenesisTCGA |
| spellingShingle | Jinfa Huang Guilian Wang Kedan Liao Ning Xie Kaixian Deng UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients Journal of Ovarian Research Ovarian cancer UCP1 Immune infiltration level Tumorigenesis TCGA |
| title | UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients |
| title_full | UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients |
| title_fullStr | UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients |
| title_full_unstemmed | UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients |
| title_short | UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients |
| title_sort | ucp1 modulates immune infiltration level and survival outcome in ovarian cancer patients |
| topic | Ovarian cancer UCP1 Immune infiltration level Tumorigenesis TCGA |
| url | https://doi.org/10.1186/s13048-022-00951-z |
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