Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
As part of the Reproducibility Project: Cancer Biology, we published Registered Reports that described how we intended to replicate selected experiments from 29 high-impact preclinical cancer biology papers published between 2010 and 2012. Replication experiments were completed and Replication Studi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2021-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/73430 |
| _version_ | 1828195283423461376 |
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| author | Timothy M Errington Alexandria Denis Anne B Allison Renee Araiza Pedro Aza-Blanc Lynette R Bower Jessica Campos Heidi Chu Sarah Denson Cristine Donham Kaitlyn Harr Babette Haven Elizabeth Iorns Jennie Kwok Elysia McDonald Steven Pelech Nicole Perfito Amanda Pike Darryl Sampey Michael Settles David A Scott Vidhu Sharma Todd Tolentino Angela Trinh Rachel Tsui Brandon Willis Joshua Wood Lisa Young |
| author_facet | Timothy M Errington Alexandria Denis Anne B Allison Renee Araiza Pedro Aza-Blanc Lynette R Bower Jessica Campos Heidi Chu Sarah Denson Cristine Donham Kaitlyn Harr Babette Haven Elizabeth Iorns Jennie Kwok Elysia McDonald Steven Pelech Nicole Perfito Amanda Pike Darryl Sampey Michael Settles David A Scott Vidhu Sharma Todd Tolentino Angela Trinh Rachel Tsui Brandon Willis Joshua Wood Lisa Young |
| author_sort | Timothy M Errington |
| collection | DOAJ |
| description | As part of the Reproducibility Project: Cancer Biology, we published Registered Reports that described how we intended to replicate selected experiments from 29 high-impact preclinical cancer biology papers published between 2010 and 2012. Replication experiments were completed and Replication Studies reporting the results were submitted for 18 papers, of which 17 were accepted and published by eLife with the rejected paper posted as a preprint. Here, we report the status and outcomes obtained for the remaining 11 papers. Four papers initiated experimental work but were stopped without any experimental outcomes. Two papers resulted in incomplete outcomes due to unanticipated challenges when conducting the experiments. For the remaining five papers only some of the experiments were completed with the other experiments incomplete due to mundane technical or unanticipated methodological challenges. The experiments from these papers, along with the other experiments attempted as part of the Reproducibility Project: Cancer Biology, provides evidence about the challenges of repeating preclinical cancer biology experiments and the replicability of the completed experiments. |
| first_indexed | 2024-04-12T09:41:03Z |
| format | Article |
| id | doaj.art-73392eb4aa1a4b83b3d793acdbcdec17 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:41:03Z |
| publishDate | 2021-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-73392eb4aa1a4b83b3d793acdbcdec172022-12-22T03:38:04ZengeLife Sciences Publications LtdeLife2050-084X2021-12-011010.7554/eLife.73430Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer BiologyTimothy M Errington0https://orcid.org/0000-0002-4959-5143Alexandria Denis1Anne B Allison2https://orcid.org/0000-0002-6941-3159Renee Araiza3Pedro Aza-Blanc4Lynette R Bower5Jessica Campos6Heidi Chu7Sarah Denson8Cristine Donham9https://orcid.org/0000-0002-5590-7502Kaitlyn Harr10Babette Haven11Elizabeth Iorns12https://orcid.org/0000-0002-5515-1258Jennie Kwok13Elysia McDonald14Steven Pelech15Nicole Perfito16Amanda Pike17Darryl Sampey18Michael Settles19David A Scott20https://orcid.org/0000-0002-8668-2449Vidhu Sharma21Todd Tolentino22Angela Trinh23Rachel Tsui24Brandon Willis25Joshua Wood26Lisa Young27Center for Open Science, Charlottesville, United StatesCenter for Open Science, Charlottesville, United StatesPiedmont Virginia Community College, Charlottesville, United StatesUniversity of California, Davis, Davis, United StatesIndependent consultant, San Diego, United StatesUniversity of California, Davis, Davis, United StatesUniversity of California, Davis, Davis, United StatesApplied Biological Materials, Richmond, CanadaUniversity of California, Davis, Davis, United StatesUniversity of Georgia, Athens, United StatesUniversity of Virginia, Charlottesville, United StatesAbsorption Systems, Exton, United StatesScience Exchange, Palo Alto, United StatesApplied Biological Materials, Richmond, CanadaDrexel University College of Medicine, Philadelphia, United StatesKinexus Bioinformatics, Vancouver, Canada; University of British Columbia, Vancouver, United StatesScience Exchange, Palo Alto, United StatesApplied Biological Materials, Richmond, CanadaBioFactura, Frederick, United StatesIndependent consultant, Naples, United StatesSanford Burnham Prebys Medical Discovery Institute, La Jolla, United StatesApplied Biological Materials, Richmond, CanadaUniversity of California, Davis, Davis, United StatesApplied Biological Materials, Richmond, CanadaScience Exchange, Palo Alto, United StatesUniversity of California, Davis, Davis, United StatesUniversity of California, Davis, Davis, United StatesApplied Biological Materials, Richmond, CanadaAs part of the Reproducibility Project: Cancer Biology, we published Registered Reports that described how we intended to replicate selected experiments from 29 high-impact preclinical cancer biology papers published between 2010 and 2012. Replication experiments were completed and Replication Studies reporting the results were submitted for 18 papers, of which 17 were accepted and published by eLife with the rejected paper posted as a preprint. Here, we report the status and outcomes obtained for the remaining 11 papers. Four papers initiated experimental work but were stopped without any experimental outcomes. Two papers resulted in incomplete outcomes due to unanticipated challenges when conducting the experiments. For the remaining five papers only some of the experiments were completed with the other experiments incomplete due to mundane technical or unanticipated methodological challenges. The experiments from these papers, along with the other experiments attempted as part of the Reproducibility Project: Cancer Biology, provides evidence about the challenges of repeating preclinical cancer biology experiments and the replicability of the completed experiments.https://elifesciences.org/articles/73430replicationreproducibilitytransparencymethodologyopen sciencenull results |
| spellingShingle | Timothy M Errington Alexandria Denis Anne B Allison Renee Araiza Pedro Aza-Blanc Lynette R Bower Jessica Campos Heidi Chu Sarah Denson Cristine Donham Kaitlyn Harr Babette Haven Elizabeth Iorns Jennie Kwok Elysia McDonald Steven Pelech Nicole Perfito Amanda Pike Darryl Sampey Michael Settles David A Scott Vidhu Sharma Todd Tolentino Angela Trinh Rachel Tsui Brandon Willis Joshua Wood Lisa Young Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology eLife replication reproducibility transparency methodology open science null results |
| title | Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology |
| title_full | Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology |
| title_fullStr | Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology |
| title_full_unstemmed | Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology |
| title_short | Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology |
| title_sort | experiments from unfinished registered reports in the reproducibility project cancer biology |
| topic | replication reproducibility transparency methodology open science null results |
| url | https://elifesciences.org/articles/73430 |
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