Exploration and Modulation of Antibody Fragment Biophysical Properties by Replacing the Framework Region Sequences

Exploration and Modulation of Antibody Fragment Biophysical Properties by Replacing the Framework Region Sequences

In order to increase the successful development of recombinant antibodies and fragments, it seems fundamental to enhance their expression and/or biophysical properties, such as the thermal, chemical, and pH stabilities. In this study, we employed a method bases on replacing the antibody framework re...

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Bibliographic Details
Main Authors: Thomas Cnudde, Zineb Lakhrif, Justine Bourgoin, Fanny Boursin, Catherine Horiot, Corinne Henriquet, Anne di Tommaso, Matthieu Olivier Juste, Isabella Gizzi Jiacomini, Isabelle Dimier-Poisson, Martine Pugnière, Marie-Nöelle Mévélec, Nicolas Aubrey
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Antibodies
Subjects:
engineering
framework regions
Protein L (PpL)
single-chain Fragment variable (scFv)
stabilities
production
Online Access:https://www.mdpi.com/2073-4468/9/2/9

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