Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease

Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease

Abstract Introduction Down syndrome (DS), a genetic variant of early onset Alzheimer's disease (AD), lacks a suitable outcome measure for prevention trials targeting pre‐dementia stages. Methods We used cognitive test data collected in several longitudinal aging studies internationally from 312...

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Bibliographic Details
Main Authors: Andrew J. Aschenbrenner, R. Asaad Baksh, Bessy Benejam, Jessica A. Beresford‐Webb, Antonia Coppus, Juan Fortea, Benjamin L. Handen, Sigan Hartley, Elizabeth Head, Judith Jaeger, Johannes Levin, Sandra V. Loosli, Anne‐Sophie Rebillat, Silvia Sacco, Frederick A. Schmitt, Kate E. Thurlow, Shahid Zaman, Jason Hassenstab, Andre Strydom
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
clinical trial outcome
composite measure
Down syndrome
early cognitive decline
Online Access:https://doi.org/10.1002/dad2.12184

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