Neurofibromatosis type 1-associated tumours: Their somatic mutational spectrum and pathogenesis

Neurofibromatosis type 1-associated tumours: Their somatic mutational spectrum and pathogenesis

<p>Abstract</p> <p>Somatic gene mutations constitute key events in the malignant transformation of human cells. Somatic mutation can either actively speed up the growth of tumour cells or relax the growth constraints normally imposed upon them, thereby conferring a selective (proli...

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Bibliographic Details
Main Authors: Spyk Sebastian, Thomas Nick, Cooper David N, Upadhyaya Meena
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Human Genomics
Subjects:
NF1
somatic mutations
germline mutations
pathogenesis
tumorigenesis
tumour
benign
malignant
Online Access:http://www.humgenomics.com/content/5/6/623

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