Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications

Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications

Osteomyelitis and orthopedic infections are major clinical problems, limited by a lack of antibiotics specialized for such applications. In this paper, we describe the design and synthesis of a novel bone-binding antibiotic (BBA-1) and its subsequent structural and functional characterization. The s...

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Bibliographic Details
Main Authors: Sumedh Kamble, Peter Valtchev, Aiken Dao, Théophile Pelras, Michael J Rogers, Paul B. Savage, Fariba Dehghani, Aaron Schindeler
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
BBA-1
bone infection
osteomyelitis
CSA-90
alendronate
antimicrobial
Online Access:https://www.mdpi.com/1420-3049/26/6/1541

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